Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis - Wikidata - wikimedia - TriplyDB

Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis

Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis

http://www.wikidata.org/entity/Q28512497

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Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage Insights into APC/C: from cellular function to diseases and therapeutics Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.The Cell Killing Mechanisms of Hydroxyurea Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion Cell cycle-regulated protein abundance changes in synchronously proliferating HeLa cells include regulation of pre-mRNA splicing proteins Evolution and regulation of cellular periodic processes: a role for paralogues The conserved Lys-95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit M2 Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis.Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition.p53 and mitochondrial function in neurons.Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability Identification and characterization of alternative promoters, transcripts and protein isoforms of zebrafish R2 gene.Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene.Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control.Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors.Reciprocal regulation of autophagy and dNTP pools in human cancer cells.Studies of ribonucleotide reductase in crucian carp-an oxygen dependent enzyme in an anoxia tolerant vertebrate.Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit.Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling.APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.The contribution of CMP kinase to the efficiency of DNA repair Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage.Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway.MEK2 regulates ribonucleotide reductase activity through functional interaction with ribonucleotide reductase small subunit p53R2.Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species.RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence.PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress.

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P248

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P2860

Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis

http://www.wikidata.org/entity/Q28512497

description

2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

article publié dans les Procee ...... f the United States of America

@fr

artículu científicu espublizáu en 2003

@ast

im April 2003 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2003/04/01)

@sk

vědecký článek publikovaný v roce 2003

@cs

wetenschappelijk artikel (gepubliceerd op 2003/04/01)

@nl

наукова стаття, опублікована у квітні 2003

@uk

name

Mouse ribonucleotide reductase ...... plex-Cdh1-mediated proteolysis

@ast

Mouse ribonucleotide reductase ...... plex-Cdh1-mediated proteolysis

@en

Mouse ribonucleotide reductase ...... plex-Cdh1-mediated proteolysis

@nl

type

label

Mouse ribonucleotide reductase ...... plex-Cdh1-mediated proteolysis

@ast

Mouse ribonucleotide reductase ...... plex-Cdh1-mediated proteolysis

@en

Mouse ribonucleotide reductase ...... plex-Cdh1-mediated proteolysis

@nl

prefLabel

Mouse ribonucleotide reductase ...... plex-Cdh1-mediated proteolysis

@ast

Mouse ribonucleotide reductase ...... plex-Cdh1-mediated proteolysis

@en

Mouse ribonucleotide reductase ...... plex-Cdh1-mediated proteolysis

@nl

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P356

PNAS.0330774100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Mouse ribonucleotide reductase ...... plex-Cdh1-mediated proteolysis

@en

P2093

Anna Lena Chabes

http://www.w3.org/2001/XMLSchema#string

Cathie M. Pfleger

http://www.w3.org/2001/XMLSchema#string

Lars Thelander

http://www.w3.org/2001/XMLSchema#string

Marc W. Kirschner

http://www.w3.org/2001/XMLSchema#string

P2860

Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons

The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae

The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor.

Cyclin is degraded by the ubiquitin pathway

The DNA damage response: putting checkpoints in perspective

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3925–3929

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scholarly article

P3181

100879

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P356

10.1073/PNAS.0330774100

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P407

P433

7

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P478

100

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P577

2003-04-01T00:00:00Z

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10840159

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P698

12655059

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P921

Ribonucleotide reductase M2

P932

153024

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