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Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

http://www.wikidata.org/entity/Q34094598

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Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei Arabidopsis thaliana thymidine kinase 1a is ubiquitously expressed during development and contributes to confer tolerance to genotoxic stress.Nuclear-targeted siRNA delivery for long-term gene silencing.Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis.FISH comets show that the salvage enzyme TK1 contributes to gene-specific DNA repair.Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer.Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer Design, synthesis, and in vitro and in vivo biological studies of a 3'-deoxythymidine conjugate that potentially kills cancer cells selectively Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix.Early assessment of the efficacy of temozolomide chemotherapy in experimental glioblastoma using [18F]FLT-PET imaging.Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.Discriminant analysis of ¹⁸F-fluorothymidine kinetic parameters to predict survival in patients with recurrent high-grade glioma.Validation of a network-based strategy for the optimization of combinatorial target selection in breast cancer therapy: siRNA knockdown of network targets in MDA-MB-231 cells as an in vitro model for inhibition of tumor development.Trafficking of intracellular folates.Targeting nuclear thymidylate biosynthesis.Pharmacodynamic evaluation of irinotecan therapy by FDG and FLT PET/CT imaging in a colorectal cancer xenograft model.Serum TK1 is a more reliable marker than CEA and AFP for cancer screening in a study of 56,286 people.Biomarker analysis and clinical relevance of TK1 on the cell membrane of Burkitt's lymphoma and acute lymphoblastic leukemia.Sensitizing cancer cells: is it really all about U?Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses.Deoxyribonucleotide metabolism in cycling and resting human fibroblasts with a missense mutation in p53R2, a subunit of ribonucleotide reductase.The proliferation marker thymidine kinase 1 in clinical use Monitoring tumor response with radiolabeled nucleoside analogs in a hepatoma-bearing mouse model early after doxisome(®) treatment.Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis.Metformin-induced alterations in nucleotide metabolism cause 5-fluorouracil resistance but gemcitabine susceptibility in oesophageal squamous cell carcinoma.Clinical significance and diagnostic capacity of serum TK1, CEA, CA 19-9 and CA 72-4 levels in gastric and colorectal cancer patients.High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma.Nm23-H1 is involved in the repair of ionizing radiation-induced DNA double-strand breaks in the A549 lung cancer cell line.

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Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

http://www.wikidata.org/entity/Q34094598

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

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Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

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Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

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Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

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Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

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Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

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Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

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Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

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JBC.M110.137042

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Journal of Biological Chemistry

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Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage

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Staffan Eriksson

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Yen-Ling Chen

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Zee-Fen Chang

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P2860

Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2

Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth

The DNA-damage response in human biology and disease

Control of thymidine kinase mRNA during the cell cycle

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

Mammalian deoxyribonucleoside kinases

A ribonucleotide reductase gene is a transcriptional target of p53 and p73

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

5-fluorouracil: mechanisms of action and clinical strategies

p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint

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27327-27335

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