Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity
about
d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophreniaSerine racemase: a key player in apoptosis and necrosisRole for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice.Crystal Structure of a Homolog of Mammalian Serine Racemase from Schizosaccharomyces pombeCrystal Structure of a Zinc-dependent D-Serine Dehydratase from Chicken KidneyModulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemaseMeta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophreniaInhibition of D-serine accumulation in the Xenopus oocyte by expression of the rat ortholog of human 3'-phosphoadenosine 5'-phosphosulfate transporter gene isolated from the neocortex as D-serine modulator-1Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formationGenetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice.Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.Localization of serine racemase and its role in the skinEpigenetic Activation of ASCT2 in the Hippocampus Contributes to Depression-Like Behavior by Regulating D-Serine in Mice.Heterogeneity of D-Serine Distribution in the Human Central Nervous System.The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment.Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.D-serine and serine racemase are localized to neurons in the adult mouse and human forebrainCross-linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species.Addressing the Conformational Flexibility of Serine Racemase by Combining Targeted Molecular Dynamics, Conformational Sampling and Docking Studies.Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.D-Serine Production, Degradation, and Transport in ALS: Critical Role of MethodologyCell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neuronsGenetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in miceD-serine signalling as a prominent determinant of neuronal-glial dialogue in the healthy and diseased brainSerine racemase: an unconventional enzyme for an unconventional transmitter.The pleiotropic effect of vitamin d.Environmental roles of microbial amino acid racemases.Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.D-Amino Acids in the Nervous and Endocrine Systems.D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine.An overview on D-amino acids.Phosphorylation of mouse serine racemase regulates D-serine synthesis.D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).Distribution and evolution of the serine/aspartate racemase family in invertebrates.Eph signaling regulates gliotransmitter release.EphrinBs regulate D-serine synthesis and release in astrocytes.
P2860
Q24294371-ADBD0D8C-17B2-4455-A04B-ECFCE54745A9Q27025560-23A48698-460D-4C28-B2DE-A4E7B95EE948Q27319213-AEB7FE92-96CD-43A6-9BDA-EE03024513E7Q27656759-D36454FB-D279-4328-81F8-4EEA90B4A52BQ27670452-BCF3ED39-18C6-42C6-87A8-C0399AC64375Q28241525-90CD31D0-F7C6-43CA-9B7A-E192D4487C33Q28248687-AEE2D09E-2238-4F67-83EC-549F02B8D2A4Q28576131-522A1A8B-DAAE-46BF-A2E5-A51D70202C47Q28587310-254E2B84-AF4C-49BB-B902-7C9A0C07FFE4Q30477241-ADB5363F-898B-4FF2-8676-ED5845A755DCQ30479725-9774B77E-A30C-40D4-87A7-4D942D5B617BQ33611796-26FE66AB-A1F0-41FF-9E1C-155B7D490B6CQ33614932-C105F672-7EFE-4CCE-AEAB-95987C6BE6C0Q33650476-E1B5AED9-F5AE-497D-AB88-0026BC683264Q33797251-4D5D2C66-9792-4E26-BD81-9F143B3E9187Q33920257-AA6D9FEF-015C-4E9E-A862-D43491B0E789Q34438746-391D68CC-652B-40B5-8ADC-E12105F5AD8BQ34727367-17031180-C81F-4B11-903F-B9010B03B212Q35860359-0FC57877-54CF-4877-814F-DB9538CAB9EDQ35881536-11F84F6C-C49E-4270-866E-C9436DE9230EQ36088275-3CBC9624-30F5-4FC6-A4EB-D9F4A90778C4Q36100570-0E36095B-C01F-463A-9162-0F4D2DC374A2Q36279687-B8C9B1EB-1B1C-472A-ABD1-45FF78B75CDFQ36755574-22FACBAA-E5FF-40DE-AD55-10ADEBFF2877Q37077292-7D51C989-CCED-4BEF-BF38-A093B0551B45Q37118079-8DBD1D82-BDCE-40A9-ABA1-686E418D2B27Q38030879-2A2B90BD-5894-42C1-955B-0F34A4CC84E6Q38223423-546FF807-E994-41C5-AA51-A1634DCF2E07Q38595346-7F5CA149-AEEE-424A-A19A-ACE2959AA213Q38684460-099B50B7-AC60-44A5-B544-4D614CF53489Q38945929-BF17EB72-8F1A-4246-893E-2B3C3E86A647Q39062810-96FCEA78-E96F-4EFC-B1EB-123A0002F6ACQ39067787-138A6DF8-72FA-43F5-A278-266D9F904F83Q39394930-E1F87A6B-584C-40DE-99C3-685A822602ECQ39417321-DE54E121-1B5D-402E-9213-9C2A8046C60AQ39701333-783D3519-4272-433C-AA62-E424AAFB5DC3Q39749489-E9355591-7CD7-46CA-9EB1-43705B87EFE9Q40559700-D232C997-AFCE-4373-81F5-F99E098DB8EBQ41874374-37458C2D-E57F-4C17-8800-7F9DD5DA951CQ42130459-328CC809-A5E7-4BCA-945D-DCA169B1B709
P2860
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity
description
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2005
@ast
im Januar 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/01/21)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/01/21)
@nl
наукова стаття, опублікована в січні 2005
@uk
name
Serine racemase modulates intr ...... lpha,beta-elimination activity
@ast
Serine racemase modulates intr ...... lpha,beta-elimination activity
@en
Serine racemase modulates intr ...... lpha,beta-elimination activity
@nl
type
label
Serine racemase modulates intr ...... lpha,beta-elimination activity
@ast
Serine racemase modulates intr ...... lpha,beta-elimination activity
@en
Serine racemase modulates intr ...... lpha,beta-elimination activity
@nl
prefLabel
Serine racemase modulates intr ...... lpha,beta-elimination activity
@ast
Serine racemase modulates intr ...... lpha,beta-elimination activity
@en
Serine racemase modulates intr ...... lpha,beta-elimination activity
@nl
P2093
P2860
P356
P1476
Serine racemase modulates intr ...... lpha,beta-elimination activity
@en
P2093
Elena Dumin
Elena Kartvelishvily
Inna Bendikov
Joari De Miranda
Maria Shleper
Michael D Toney
Rogerio Panizzutti
Veronika N Foltyn
P2860
P304
P356
10.1074/JBC.M405726200
P407
P50
P577
2004-11-09T00:00:00Z