A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesInternational Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyBlood cells: an historical account of the roles of purinergic signallingThe Inflammatory Role of Platelets via Their TLRs and Siglec ReceptorsCalcium influx pathways in breast cancer: opportunities for pharmacological interventionPrimary and secondary agonists can use P2X(1) receptors as a major pathway to increase intracellular Ca(2+) in the human plateletP2X7 receptors induce degranulation in human mast cellsIdentification of a tsetse fly salivary protein with dual inhibitory action on human platelet aggregationDisruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstrictionPhysiological role for P2X1 receptors in renal microvascular autoregulatory behaviorHeat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness.MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in miceSp1/3 and NF-1 mediate basal transcription of the human P2X1 gene in megakaryoblastic MEG-01 cells.P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation.Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth.ATP-gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation.Purinergic control of inflammation and thrombosis: Role of P2X1 receptorsCRAC channelopathies.P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes.Amplification of human platelet activation by surface pannexin-1 channels.P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in miceMolecular recognition at adenine nucleotide (P2) receptors in platelets.P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions.Emerging roles for P2X1 receptors in platelet activation.Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice.Platelets in atherothrombosis: lessons from mouse models.Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor.Platelet P2 receptors: old and new targets for antithrombotic drugs.Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.A guide to murine platelet structure, function, assays, and genetic alterations.A Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 ReceptorsFunctional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells.P2X(1) receptor inhibition and soluble CD39 administration as novel approaches to widen the cardiovascular therapeutic windowThe P2X1 ion channel in platelet function.New structure enlivens interest in P2X receptors.Platelet receptor signaling in thrombus formation.Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death.Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity.
P2860
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P2860
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
description
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im August 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/08/18)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/08/18)
@nl
наукова стаття, опублікована в серпні 2003
@uk
مقالة علمية (نشرت في 18-8-2003)
@ar
name
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
@ast
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
@en
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
@nl
type
label
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
@ast
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
@en
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
@nl
prefLabel
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
@ast
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
@en
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
@nl
P2093
P2860
P50
P3181
P356
P1476
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
@en
P2093
Béatrice Hechler
Marco Cattaneo
Monique Freund
Nadege Lenain
Patrizia Marchese
Richard Evans
Véronique Heim
Zaverio M. Ruggeri
P2860
P304
P3181
P356
10.1084/JEM.20030144
P407
P577
2003-08-18T00:00:00Z