Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.
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Molecular and functional properties of P2X receptors--recent progress and persisting challengesExploring the ATP-binding site of P2X receptorsSize matters in activation/inhibition of ligand-gated ion channelsCharacterization of ATPase Activity of P2RX2 Cation ChannelMolecular mechanism of ATP binding and ion channel activation in P2X receptorsHeat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness.A P2X receptor from the tardigrade species Hypsibius dujardini with fast kinetics and sensitivity to zinc and copper.A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptorIdentification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains.Agonist trapped in ATP-binding sites of the P2X2 receptor.Activation and regulation of purinergic P2X receptor channelsPreferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulationsCHARMM-GUI PDB manipulator for advanced modeling and simulations of proteins containing nonstandard residues.New structure enlivens interest in P2X receptors.Structural interpretation of P2X receptor mutagenesis studies on drug actionHeteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Ectodomain movements of an ATP-gated ion channel (P2X2 receptor) probed by disulfide locking.Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gatingShort- and long-term (trophic) purinergic signalling.P2X Receptor Activation.Modeling Interactions among Individual P2 Receptors to Explain Complex Response Patterns over a Wide Range of ATP Concentrations.Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function.Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop.Regulation of Pannexin 1 Surface Expression by Extracellular ATP: Potential Implications for Nervous System Function in Health and Disease.Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis.Functional characterization of intracellular Dictyostelium discoideum P2X receptors.Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.Amino acid residues constituting the agonist binding site of the human P2X3 receptorAmino acid variations resulting in functional and nonfunctional zebrafish P2X(1) and P2X (5.1) receptors.
P2860
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P2860
Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Cysteine substitution mutagene ...... f ATP action at P2X receptors.
@ast
Cysteine substitution mutagene ...... f ATP action at P2X receptors.
@en
type
label
Cysteine substitution mutagene ...... f ATP action at P2X receptors.
@ast
Cysteine substitution mutagene ...... f ATP action at P2X receptors.
@en
prefLabel
Cysteine substitution mutagene ...... f ATP action at P2X receptors.
@ast
Cysteine substitution mutagene ...... f ATP action at P2X receptors.
@en
P2093
P2860
P356
P1476
Cysteine substitution mutagene ...... of ATP action at P2X receptors
@en
P2093
Helen R Digby
Jonathan A Roberts
Madina Kara
Richard J Evans
Sam El Ajouz
P2860
P304
20126-20136
P356
10.1074/JBC.M800294200
P407
P577
2008-05-16T00:00:00Z