Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant
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The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and PerspectiveRoles of Zinc Signaling in the Immune SystemMolecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins.Prolactin (PRL)-stimulated ubiquitination of ZnT2 mediates a transient increase in zinc secretion followed by ZnT2 degradation in mammary epithelial cells.Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis.High frequency of symptomatic zinc deficiency in infants in northern ethiopiaParadoxical zinc toxicity and oxidative stress in the mammary gland during marginal dietary zinc deficiency.Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathwayHeterodimerization, altered subcellular localization, and function of multiple zinc transporters in viable cells using bimolecular fluorescence complementationExtensive variation between tissues in allele specific expression in an outbred mammal.Essential Role for Zinc Transporter 2 (ZnT2)-mediated Zinc Transport in Mammary Gland Development and Function during Lactation.Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milkSpondylocheirodysplastic Ehlers-Danlos syndrome (SCD-EDS) and the mutant zinc transporter ZIP13.Infants and elderlies are susceptible to zinc deficiencyZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactationMolecular Basis of Transient Neonatal Zinc Deficiency: NOVEL ZnT2 MUTATIONS DISRUPTING ZINC BINDING AND PERMEATION.ZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary for Coordinated Secretion and Paneth Cell Function in Mice.In situ dimerization of multiple wild type and mutant zinc transporters in live cells using bimolecular fluorescence complementation.The biology of zinc transport in mammary epithelial cells: implications for mammary gland development, lactation, and involution.Current understanding of ZIP and ZnT zinc transporters in human health and diseases.The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activationDirect Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter.Biological underpinnings of breastfeeding challenges: the role of genetics, diet, and environment on lactation physiology.TNFα Post-Translationally Targets ZnT2 to Accumulate Zinc in Lysosomes.The role of the zinc transporter SLC30A2/ZnT2 in transient neonatal zinc deficiency.Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity.Novel mutations in SLC30A2 involved in the pathogenesis of transient neonatal zinc deficiency.Understanding the Contribution of Zinc Transporters in the Function of the Early Secretory Pathway.Zinc as a Gatekeeper of Immune Function.Zinc Transporter Proteins.Zinc transporter 2 interacts with vacuolar ATPase and is required for polarization, vesicle acidification, and secretion in mammary epithelial cells.Zinc and Skin Disorders.A genetic variant in SLC30A2 causes breast dysfunction during lactation by inducing ER stress, oxidative stress and epithelial barrier defects.Transient Neonatal Zinc Deficiency Caused by a Novel Mutation in the SLC30A2 Gene.Properties of Zip4 accumulation during zinc deficiency and its usefulness to evaluate zinc status: a study of the effects of zinc deficiency during lactation.Concentration Profiles of Metals in Breast Milk, Drinking Water, and Soil: Relationship Between MatricesEvaluation of the roles of the cytosolic N-terminus and His-rich loop of ZNT proteins using ZNT2 and ZNT3 chimeric mutants
P2860
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P2860
Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant
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2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
Compound heterozygous mutation ...... iciency in a breast-fed infant
@ast
Compound heterozygous mutation ...... iciency in a breast-fed infant
@en
Compound heterozygous mutation ...... iciency in a breast-fed infant
@nl
type
label
Compound heterozygous mutation ...... iciency in a breast-fed infant
@ast
Compound heterozygous mutation ...... iciency in a breast-fed infant
@en
Compound heterozygous mutation ...... iciency in a breast-fed infant
@nl
prefLabel
Compound heterozygous mutation ...... iciency in a breast-fed infant
@ast
Compound heterozygous mutation ...... iciency in a breast-fed infant
@en
Compound heterozygous mutation ...... iciency in a breast-fed infant
@nl
P2093
P2860
P3181
P1433
P1476
Compound heterozygous mutation ...... iciency in a breast-fed infant
@en
P2093
Fumie Teranishi
Fumiko Okazaki
Hiroko Kodama
Hiroshi Narita
Naoya Itsumura
Yasuji Inamo
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0064045
P407
P50
P577
2013-05-31T00:00:00Z