Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia

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Dual Inhibition of Topoisomerase II and Tyrosine Kinases by the Novel Bis-Fluoroquinolone Chalcone-Like Derivative HMNE3 in Human Pancreatic Cancer Cells Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability.

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Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induc ...... Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induc ...... Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induc ...... Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induc ...... Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induc ...... Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induc ...... Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induc ...... Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induc ...... Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induc ...... Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induc ...... Topoisomerase II under Hypoxia

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P2093

Bo Yang

http://www.w3.org/2001/XMLSchema#string

Dandan Wang

http://www.w3.org/2001/XMLSchema#string

Jian Ma

http://www.w3.org/2001/XMLSchema#string

Linlin Chang

http://www.w3.org/2001/XMLSchema#string

Qiaojun He

http://www.w3.org/2001/XMLSchema#string

Rong Sheng

http://www.w3.org/2001/XMLSchema#string

Tianyi Zhou

http://www.w3.org/2001/XMLSchema#string

Xiaowen Liu

http://www.w3.org/2001/XMLSchema#string

Ying Chen

http://www.w3.org/2001/XMLSchema#string

Ying Du

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P2860

The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients

Targeting HIF-1 for cancer therapy

Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast.

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

ATM and ATR: networking cellular responses to DNA damage

Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma

Targeting hypoxia in cancer therapy

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

AQ4N: a new approach to hypoxia-activated cancer chemotherapy.

Targeting tumors with hypoxia-activated cytotoxins.

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10.1371/JOURNAL.PONE.0144506

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English

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Hong Zhu

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2015-12-09T00:00:00Z

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hypoxia

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Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia

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Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia

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