ATM and ATR: networking cellular responses to DNA damage
about
MicroRNAs in the DNA Damage/Repair Network and CancerHuman SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decaySMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointPhosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damageHighlight: BRCA1 and BRCA2 proteins in breast cancerThe cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cellsATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylationTyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulationPhosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damageMinichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinasesHuman Claspin works with BRCA1 to both positively and negatively regulate cell proliferationmiRNA response to DNA damageProapoptotic Bid mediates the Atr-directed DNA damage response to replicative stressPrevention of DNA re-replication in eukaryotic cellsKruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damageRapid activation of ATR by ionizing radiation requires ATM and Mre11Fission yeast Rad26 responds to DNA damage independently of Rad3Genetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damage.Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage ResponseThe Fanconi anaemia/BRCA pathwayATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responsesBRCA1 associates with processive RNA polymerase IIHuman claspin is required for replication checkpoint controlPhosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domainsViral infections and cell cycle G2/M regulationThe ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytesBRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damageATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damageRegulating mammalian checkpoints through Cdc25 inactivation.CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancerRad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stabilityHistone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stabilityHypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under HypoxiaImproved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasionPromyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.Udu deficiency activates DNA damage checkpoint.Cell cycle-dependent localization of CHK2 at centrosomes during mitosis.Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.Specific recruitment of human cohesin to laser-induced DNA damage.Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response.
P2860
Q21284509-6333E98A-207B-447A-AB93-ECB84E6CF4E8Q24291647-817C35E1-7D62-4460-A102-A1D7CF97B903Q24292395-8644164A-01C1-43C4-AD0A-0637AE4A3D8FQ24300758-A9534C11-9EA6-4A04-81BA-DBAF2D4ED5ADQ24307401-C64EDAD2-8B19-4599-B6D3-92CD1F1EAD11Q24317260-1985B8E5-FE60-46C2-AFF6-58D3EA3C2997Q24523440-C2E68EB8-6E19-482F-8B79-71606E8AC7C2Q24534983-EA02079A-2AF7-4625-A657-84E91A6DD9E4Q24555104-AA2F4FFC-4F32-453C-93FD-7B360D930A1BQ24564474-BD0B07AF-9953-4668-9472-DFBB089FA08CQ24564847-AA468EAD-E143-445F-B6FE-1D4EE1BA9C4AQ24594312-1DF9EF81-F953-4B54-BA06-FB5BB7F8C785Q24620829-4499D7E9-065A-4ECE-957E-0D79C1091280Q24632601-6C602AB7-D952-4C14-A724-4AE50A7183CCQ24655032-A879D01C-E9F8-418E-9C79-0993CBED9901Q24680246-62279C38-ED65-4497-8A35-8AFA2DC37C3AQ24796924-418F528A-E9B8-460D-B166-0E05DC116CF4Q27936447-D347973D-8292-4751-8EBB-930146F0E469Q28070247-0C03C865-0A26-4C29-9826-495CA7A6A97BQ28201371-67246A79-3F2E-4AB4-96D8-33A6FFDD7D1EQ28202998-8A15BEEF-1B9F-4018-984F-A4C5EE8B2565Q28204666-A7E12891-3DF8-4433-A119-40AB63C5E843Q28206333-29C6D9FF-FD2B-4CD5-B312-22148578A9A4Q28212425-6E3AD268-FC90-4DC6-A576-5FFF517A9949Q28240818-3E01BF7D-CA22-4B03-9DCB-BD81044F052CQ28241779-F6CC1C4B-EF96-4163-BEB2-78BECF43ED62Q28263101-6D5A04AF-D29A-409C-AEF8-7037CA3C85B1Q28364113-10024DCB-5A5C-4EF2-B5AA-D94D28F62E5AQ28387035-304747CD-E410-4F1B-9F04-63010F8A327FQ28473504-2E92FD10-8CB0-4B0D-84D7-3603AEDAD5CFQ28506612-1FB26D5D-76D8-4F00-87A6-8B6199C78D40Q28509626-4D02CEC8-5FC7-4450-B21C-C1B94EF6157FQ28551450-76A4B1A5-E24E-4D2A-A072-F9BF24D2FCB0Q30434675-1A1E7149-0FF3-4A1A-8CF5-E0EC0EB4BCB0Q30480527-E3FB0983-0D45-4992-B2B8-E261E92F6497Q30490662-AAADF2B3-B2A4-4C0E-9695-9A7A9EEC0664Q30540177-48EEA429-BB3D-432D-9684-C91DA8985F24Q30831287-5E6D43C4-A29E-49A1-8B5F-359E20C98C20Q30847802-7FFB23CD-9B12-4B45-B580-5A05E103116DQ33186627-BC7775E9-728C-4385-AE77-349FFF0C5E4E
P2860
ATM and ATR: networking cellular responses to DNA damage
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
ATM and ATR: networking cellular responses to DNA damage
@ast
ATM and ATR: networking cellular responses to DNA damage
@en
ATM and ATR: networking cellular responses to DNA damage
@nl
type
label
ATM and ATR: networking cellular responses to DNA damage
@ast
ATM and ATR: networking cellular responses to DNA damage
@en
ATM and ATR: networking cellular responses to DNA damage
@nl
prefLabel
ATM and ATR: networking cellular responses to DNA damage
@ast
ATM and ATR: networking cellular responses to DNA damage
@en
ATM and ATR: networking cellular responses to DNA damage
@nl
P3181
P1476
ATM and ATR: networking cellular responses to DNA damage
@en
P2093
P3181
P356
10.1016/S0959-437X(00)00159-3
P407
P577
2001-02-01T00:00:00Z