Biosynthesis of surfactant protein C (SP-C). Sorting of SP-C proprotein involves homomeric association via a signal anchor domain
about
A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activationHigh-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residuesC-terminal, endoplasmic reticulum-lumenal domain of prosurfactant protein C - structural features and membrane interactions.Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-CCharacterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency.ABCA3-mediated choline-phospholipids uptake into intracellular vesicles in A549 cells.A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and mitophagyA novel conserved targeting motif found in ABCA transporters mediates trafficking to early post-Golgi compartments.A nonaggregating surfactant protein C mutant is misdirected to early endosomes and disrupts phospholipid recycling.Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligasesDisruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3.Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells.Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutantsAberrant catalytic cycle and impaired lipid transport into intracellular vesicles in ABCA3 mutants associated with nonfatal pediatric interstitial lung disease.Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms.Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene.Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice.Effect of Lung Surfactant Protein SP-C and SP-C-Promoted Membrane Fragmentation on Cholesterol Dynamics.The potential of antisense oligonucleotide therapies for inherited childhood lung diseases.
P2860
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P2860
Biosynthesis of surfactant protein C (SP-C). Sorting of SP-C proprotein involves homomeric association via a signal anchor domain
description
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im Mai 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/05/31)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/05/31)
@nl
наукова стаття, опублікована в травні 2002
@uk
name
Biosynthesis of surfactant pro ...... ion via a signal anchor domain
@ast
Biosynthesis of surfactant pro ...... ion via a signal anchor domain
@en
Biosynthesis of surfactant pro ...... ion via a signal anchor domain
@nl
type
label
Biosynthesis of surfactant pro ...... ion via a signal anchor domain
@ast
Biosynthesis of surfactant pro ...... ion via a signal anchor domain
@en
Biosynthesis of surfactant pro ...... ion via a signal anchor domain
@nl
prefLabel
Biosynthesis of surfactant pro ...... ion via a signal anchor domain
@ast
Biosynthesis of surfactant pro ...... ion via a signal anchor domain
@en
Biosynthesis of surfactant pro ...... ion via a signal anchor domain
@nl
P2093
P2860
P356
P1476
Biosynthesis of surfactant pro ...... ion via a signal anchor domain
@en
P2093
Michael F. Beers
Scott J. Russo
Surafel Mulugeta
Wen-Jing Wang
P2860
P304
19929–19937
P356
10.1074/JBC.M201537200
P407
P577
2002-05-31T00:00:00Z