Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing
about
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decayA novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttlingTargeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethalityMetabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factorConvergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamilyIdentification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editaseInduction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1Mutagenesis of apobec-1 complementation factor reveals distinct domains that modulate RNA binding, protein-protein interaction with apobec-1, and complementation of C to U RNA-editing activityARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editingInhibition of the apolipoprotein B mRNA editing enzyme-complex by hnRNP C1 protein and 40S hnRNP complexesPhosphorylation is a regulatory mechanism in apolipoprotein B mRNA editingTwo regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization.APOBEC3B and AID have similar nuclear import mechanisms.Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity.Functions and regulation of the APOBEC family of proteinsApolipoprotein B RNA sequence 3' of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing.APOBEC-1-mediated RNA editing.Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons.Functional characterization of APOBEC-1 complementation factor phosphorylation sites.C to U editing at position 32 of the anticodon loop precedes tRNA 5' leader removal in trypanosomatids.Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase.Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities.RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cellsThe AID/APOBEC family of nucleic acid mutators.The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions.Identification of novel alternative splice variants of APOBEC-1 complementation factor with different capacities to support apolipoprotein B mRNA editing.The APOBEC Protein Family: United by Structure, Divergent in Function.Flow-cytometric visualization of C>U mRNA editing reveals the dynamics of the process in live cells.RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing.APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast.Nuclear Exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal and is not dependent on RNA binding.Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3' efficiency element.Active nuclear import and cytoplasmic retention of activation-induced deaminase.The role of cytidine deaminases on innate immune responses against human viral infections.Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization.APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic
P2860
Q24307678-92DCCE3E-657D-4543-BDE2-A8A7979BF85DQ24310868-AA8F56A8-BF73-4D27-AE4F-FFE93C990C7DQ24313327-23D29A6C-6190-49BE-B940-D4B0B303CDA9Q24529931-FC272C16-E7C9-40C3-A8CA-033792E541A5Q24550835-F3624835-9692-4905-BEE3-E2C6775AB81DQ24657742-A41E83DA-C7A3-423F-8BE7-388E22DEBF83Q27938986-99121551-42D4-4BB7-8A2F-73F7E0390D33Q28145492-2CA0FC03-B5AD-4F51-8C16-8F633A8FF44EQ28188677-EC14C753-EC2F-44BE-9ABE-AECDF836D6E3Q28204149-7EDD3247-4CC5-479F-95E7-5DFF49D97F21Q28286991-AB8151BB-9EEA-41ED-A79F-EF5A01F1C5E4Q28344396-0E61F297-68EE-4610-AC69-E0BF7BB14BE8Q30483676-7AB37D27-5C33-4F7C-A501-EE995E7C82E3Q30514846-4010D2EA-010F-4D7A-B6B9-DE4C184F5D71Q33587739-983A92D0-BBD1-45DC-A479-0D8E69BCF5DEQ33595661-4938605F-7953-4944-B57B-0A50D4919BC5Q34660658-C7B487D1-FC08-4471-9260-70DE7636680BQ34910421-CA09867A-2868-4764-ACAB-CE2988D2F8BEQ35120769-9F7344FD-EC39-4A4B-BF4A-1AC6411D8FE7Q35740955-B4206E1D-F02E-4296-94DF-BE59E12B5EE7Q36328837-6EF3CDC5-EAD2-44B7-8F5D-387896C49CB8Q36399510-75267454-9802-4A79-89CD-2C79AF8A919CQ36438515-545B9E92-E2EB-426B-92BB-61EFCDAC27EEQ36689901-063CE802-BBA1-4C07-B65A-DB236B66FF9EQ37206307-9C90C29D-203F-49A9-846B-877D9DAEC6AAQ38199065-0D1DDE46-838C-4137-B9CB-80E9DCBD31EBQ38348889-DDFE989D-B216-464B-81DC-0CBED640FCC5Q38860803-7B859E65-A624-4946-BDF7-E03D87BA54C2Q38895502-657CDBA3-D360-41FC-B969-1D3CB5D9AEC4Q39015203-D4635C08-548D-48D6-BF22-DB2CEA77FFEBQ39542049-E0D2EC7E-79BB-4B0E-80DC-2258D1E23F0EQ40029354-98DECD0A-1AD6-4467-8C54-3CC09105E9AFQ41704284-2A6C6616-1F47-43D6-B97C-7592B4D8595BQ41792388-DD8F8741-82D1-485A-AD41-19E49DA184DDQ41812539-99577E19-77B3-4887-92BF-9A0EA6E06613Q42060855-50C30839-178E-44C7-9CFE-CA35300085B3Q42861821-D90B380A-C01E-4D14-A8B7-D2ACE02D7EDF
P2860
Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing
description
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1997
@ast
im November 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/11/25)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/11/25)
@nl
наукова стаття, опублікована в листопаді 1997
@uk
name
Multiple protein domains deter ...... apolipoprotein B mRNA editing
@ast
Multiple protein domains deter ...... apolipoprotein B mRNA editing
@en
Multiple protein domains deter ...... apolipoprotein B mRNA editing
@nl
type
label
Multiple protein domains deter ...... apolipoprotein B mRNA editing
@ast
Multiple protein domains deter ...... apolipoprotein B mRNA editing
@en
Multiple protein domains deter ...... apolipoprotein B mRNA editing
@nl
prefLabel
Multiple protein domains deter ...... apolipoprotein B mRNA editing
@ast
Multiple protein domains deter ...... apolipoprotein B mRNA editing
@en
Multiple protein domains deter ...... apolipoprotein B mRNA editing
@nl
P2860
P356
P1476
Multiple protein domains deter ...... apolipoprotein B mRNA editing
@en
P2093
P2860
P304
13075–13080
P356
10.1073/PNAS.94.24.13075
P407
P50
P577
1997-11-25T00:00:00Z