Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index - Wikidata - wikimedia - TriplyDB

Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index

Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index

http://www.wikidata.org/entity/Q28567896

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Molecular functions of thyroid hormones and their clinical significance in liver-related diseases Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges Synthesis of nucleoside phosphate and phosphonate prodrugs Thyroid hormone analogues for the treatment of metabolic disorders: new potential for unmet clinical needs?New avenues for regulation of lipid metabolism by thyroid hormones and analogs Prodrugs of phosphonates and phosphates: crossing the membrane barrier Cross-talk between the thyroid and liver: a new target for nonalcoholic fatty liver disease treatment The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio)The thyromimetic T-0681 protects from atherosclerosis.Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.Non-alcoholic fatty liver disease and thyroid dysfunction: a systematic review.Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.In vivo selective expression of thyroid hormone receptor α1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice.Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver.Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity.Mechanisms of thyroid hormone action The resurgence of thyromimetics as lipid-modifying agents.Thyroid hormones and thyroid hormone receptors: effects of thyromimetics on reverse cholesterol transport.In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23 on rat liver, heart, and brain.Thyroid hormone potentiates insulin signaling and attenuates hyperglycemia and insulin resistance in a mouse model of type 2 diabetes A TRbeta-selective agonist confers resistance to diet-induced obesity.Thyroid hormone analogues and derivatives: Actions in fatty liver Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity.Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis.3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats.Thyroid hormone status regulates the expression of secretory phospholipases Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor.Nuclear receptors reverse McGarry's vicious cycle to insulin resistance.In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue.The Relationship between Type 2 Diabetes Mellitus and Related Thyroid Diseases.Hepatocellular carcinoma: thyroid hormone promotes tumorigenicity through inducing cancer stem-like cell self-renewal.Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways.Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys.3,5,3'-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice.American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.Thyromimetics: a review of recent reports and patents (2004 - 2009).

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Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index

http://www.wikidata.org/entity/Q28567896

description

2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

article publié dans les Procee ...... f the United States of America

@fr

artículu científicu espublizáu en 2007

@ast

im September 2007 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2007/09/25)

@sk

vědecký článek publikovaný v roce 2007

@cs

wetenschappelijk artikel (gepubliceerd op 2007/09/25)

@nl

наукова стаття, опублікована у вересні 2007

@uk

name

Targeting thyroid hormone rece ...... improves the therapeutic index

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Targeting thyroid hormone rece ...... improves the therapeutic index

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Targeting thyroid hormone rece ...... improves the therapeutic index

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type

label

Targeting thyroid hormone rece ...... improves the therapeutic index

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Targeting thyroid hormone rece ...... improves the therapeutic index

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Targeting thyroid hormone rece ...... improves the therapeutic index

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prefLabel

Targeting thyroid hormone rece ...... improves the therapeutic index

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Targeting thyroid hormone rece ...... improves the therapeutic index

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Targeting thyroid hormone rece ...... improves the therapeutic index

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Proceedings of the National Academy of Sciences of the United States of America

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Targeting thyroid hormone rece ...... improves the therapeutic index

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Bao-Hong Zhang

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Bruce R. Ito

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David L. Linemeyer

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Edward E. Cable

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Hongjian Jiang

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James M. Fujitaki

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Jinzhao Hou

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Mark D. Erion

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Patricia D. Finn

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Paul D. van Poelje

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P2860

The c-erb-A gene encodes a thyroid hormone receptor

Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1

Physiological and molecular basis of thyroid hormone action

Tissue-specific actions of thyroid hormone: insights from animal models

The c-erb-A protein is a high-affinity receptor for thyroid hormone

Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1

A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice

Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function

Hormone selectivity in thyroid hormone receptors.

MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.

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