Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia
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Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on AddictionOpioid receptor heteromers in analgesiaImportance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptorsDeficits in neuronal cytochrome P450 activity attenuate opioid analgesia but not opioid side effects.Contribution of mu and delta opioid receptors to the pharmacological profile of kappa opioid receptor subtypes.The neuroanatomy of sexual dimorphism in opioid analgesia.Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.Mu-opioid receptor splice variants: sex-dependent regulation by chronic morphine.Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism.Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.In vivo opioid receptor heteromerization: where do we stand?Allosteric interactions between δ and κ opioid receptors in peripheral sensory neuronsPleiotropic opioid regulation of spinal endomorphin 2 release and its adaptations to opioid withdrawal are sexually dimorphic.Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal morphine antinociception.Estrogens Suppress Spinal Endomorphin 2 Release in Female Rats in Phase with the Estrous Cycle.Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala.Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.Examination of sex and minocycline treatment on acute morphine-induced analgesia and inflammatory gene expression along the pain pathway in Sprague-Dawley rats.Heterodimerization with the prostacyclin receptor triggers thromboxane receptor relocation to lipid rafts.Early-in-life bladder inflammation alters U50,488H but not morphine-induced inhibition of visceromotor responses to urinary bladder distensionNeural and psychosocial contributions to sex differences in knee osteoarthritic painSex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesisOn the g-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulationProtein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs.Receptor and channel heteromers as pain targets.Stress and addiction.Mu opioids and their receptors: evolution of a concept.Sex differences in opioid analgesia and addiction: interactions among opioid receptors and estrogen receptors.Pharmacological Profiles of Oligomerized μ-Opioid Receptors.Disease-specific heteromerization of G-protein-coupled receptors that target drugs of abuseSpinal endomorphin 2 antinociception and the mechanisms that produce it are both sex- and stage of estrus cycle-dependent in rats.Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females.G-protein-coupled receptor type A heteromers as an emerging therapeutic target.Endogenous opioid system: a promising target for future smoking cessation medications.Sex Differences in Microglia Activity within the Periaqueductal Gray of the Rat: A Potential Mechanism Driving the Dimorphic Effects of Morphine.Breaking barriers to novel analgesic drug development.Selective upregulation of functional mu-opioid receptor splice variants by chronic opioids.Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat Reproductive Cycle Regulates Spinal Endomorphin 2 Antinociception: Relevance of Endogenous-Biased Agonism.Sex-related differences in acute and chronic pain: a bench to bedside perspective.Long-term ethanol effects on acute stress responses: modulation by dynorphin.
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P2860
Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia
description
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2010
@ast
im November 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/11/16)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/11/16)
@nl
наукова стаття, опублікована в листопаді 2010
@uk
name
Formation of mu-/kappa-opioid ...... male-specific opioid analgesia
@ast
Formation of mu-/kappa-opioid ...... male-specific opioid analgesia
@en
Formation of mu-/kappa-opioid ...... male-specific opioid analgesia
@nl
type
label
Formation of mu-/kappa-opioid ...... male-specific opioid analgesia
@ast
Formation of mu-/kappa-opioid ...... male-specific opioid analgesia
@en
Formation of mu-/kappa-opioid ...... male-specific opioid analgesia
@nl
prefLabel
Formation of mu-/kappa-opioid ...... male-specific opioid analgesia
@ast
Formation of mu-/kappa-opioid ...... male-specific opioid analgesia
@en
Formation of mu-/kappa-opioid ...... male-specific opioid analgesia
@nl
P2860
P356
P1476
Formation of mu-/kappa-opioid ...... male-specific opioid analgesia
@en
P2093
Alan R. Gintzler
Sumita Chakrabarti
P2860
P304
20115–20119
P356
10.1073/PNAS.1009923107
P407
P577
2010-11-16T00:00:00Z