Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
about
The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell deathParkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channelsMembrane Binding and Modulation of the PDZ Domain of PICK1Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cellsPICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose toleranceStructure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensionsClustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranesSubstrate-mediated regulation of gamma-aminobutyric acid transporter 1 in rat brainProtein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism.Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1.GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRETIdentification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1Binding free energy landscape of domain-peptide interactions.Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activationExploring Protein-Peptide Binding Specificity through Computational Peptide ScreeningInteractions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes.The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.PICK1 interacts with alpha7 neuronal nicotinic acetylcholine receptors and controls their clustering.Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering.Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.The schizophrenic faces of PICK1.Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathwayHallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors.Ubiquitination of neurotransmitter receptors and postsynaptic scaffolding proteinsMembrane localization is critical for activation of the PICK1 BAR domain.A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporterThermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study.Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization.Modulation of D-serine levels in brains of mice lacking PICK1The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains.A flexible docking scheme to explore the binding selectivity of PDZ domains.DHHC8-dependent PICK1 palmitoylation is required for induction of cerebellar long-term synaptic depression.Over-expression, rapid preparation and some properties of c-terminal BARc region in PICK1.Knowledge-based identification of the ERK2/STAT3 signal pathway as a therapeutic target for type 2 diabetes and drug discovery.Lock and Chop: A novel method for the generation of a PICK1 PDZ domain and piperidine-based inhibitor co-crystal structure.The binding affinities of proteins interacting with the PDZ domain of PICK1.PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis.
P2860
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P2860
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
description
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2005
@ast
im Mai 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/05/27)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/05/27)
@nl
наукова стаття, опублікована в травні 2005
@uk
name
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
@ast
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
@en
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
@nl
type
label
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
@ast
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
@en
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
@nl
prefLabel
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
@ast
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
@en
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
@nl
P2093
P2860
P50
P356
P1476
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
@en
P2093
Chiun-Wen Chang
Kenneth L Madsen
Thijs Beuming
P2860
P304
20539-20548
P356
10.1074/JBC.M500577200
P407
P577
2005-03-17T00:00:00Z