Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells
about
Principles of interleukin (IL)-6-type cytokine signalling and its regulationInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayStimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinaseNon-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptorDifferential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathwaysSignaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha componentSHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligandsThe COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signalingCannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowthHuman β-defensin 3 induces STAT1 phosphorylation, tyrosine phosphatase activity, and cytokine synthesis in T cells.Signaling through Gp130: toward a general scenario of cytokine action.Proinflammatory stem cell signaling in cardiac ischemiaStress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS productionStat3: linking inflammation to epithelial cancer - more than a "gut" feeling?Loss and dysregulation of Th17 cells during HIV infection.Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis.Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover.Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression.Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases.Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells.The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130.Functional interaction of STAT3 transcription factor with the cell cycle inhibitor p21WAF1/CIP1/SDI1.Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases.Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling.Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Filgotinib, a Selective JAK-1 Inhibitor, After Short-Term Treatment of Rheumatoid Arthritis: Results of Two Randomized Phase IIa Trials.Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells.Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.Sp3 is involved in the regulation of SOCS3 gene expression.ERK1/2 contributes negative regulation to STAT3 activity in HSS-transfected HepG2 cells.The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited.Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA.Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotectionThe tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells.Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.STAT3 is required for the gp130-mediated full activation of the c-myc gene.
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P2860
Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells
description
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
im März 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/03/01)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/03/01)
@nl
наукова стаття, опублікована в березні 1998
@uk
مقالة علمية (نشرت في مارس 1998)
@ar
name
Protein tyrosine phosphatase 2 ...... protein genes in hepatic cells
@ast
Protein tyrosine phosphatase 2 ...... protein genes in hepatic cells
@en
Protein tyrosine phosphatase 2 ...... protein genes in hepatic cells
@nl
type
label
Protein tyrosine phosphatase 2 ...... protein genes in hepatic cells
@ast
Protein tyrosine phosphatase 2 ...... protein genes in hepatic cells
@en
Protein tyrosine phosphatase 2 ...... protein genes in hepatic cells
@nl
prefLabel
Protein tyrosine phosphatase 2 ...... protein genes in hepatic cells
@ast
Protein tyrosine phosphatase 2 ...... protein genes in hepatic cells
@en
Protein tyrosine phosphatase 2 ...... protein genes in hepatic cells
@nl
P2093
P2860
P356
P1476
Protein tyrosine phosphatase 2 ...... protein genes in hepatic cells
@en
P2093
P2860
P304
P356
10.1128/MCB.18.3.1525
P407
P50
P577
1998-03-01T00:00:00Z