Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells
about
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayPhosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activationSelf-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptorsNon-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptorStructural and functional studies on the leukemia inhibitory factor receptor (LIF-R): gene and soluble form of LIF-R, and cytoplasmic domain of LIF-R required for differentiation and growth arrest of myeloid leukemic cellsDifferential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathwaysChoice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptorsThe conserved box 1 motif of cytokine receptors is required for association with JAK kinasesInfluence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at RasDistinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transductionTransmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cellsSeparate signaling mechanisms are involved in the control of STAT protein activation and gene regulation via the interleukin 6 response element by the box 3 motif of gp130Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cellsA single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activationLeptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerizationThe role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover.Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.Interleukin-6: structure-function relationships.Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietinMultiple cis-trans conformers of the prolactin receptor proline-rich motif (PRM) peptide detected by reverse-phase HPLC, CD and NMR spectroscopy.Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis.C/EBP-related sites in addition to a STAT site are necessary for ciliary neurotrophic factor-leukemia inhibitory factor-dependent transcriptional activation by the vasoactive intestinal peptide cytokine response element.Multiple promoter elements required for leukemia inhibitory factor-stimulated M2 muscarinic acetylcholine receptor promoter activity.Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation.Two separate signal transducer and activator of transcription proteins regulate transcription of the serine proteinase inhibitor-3 gene in hepatic cells.Molecular characterization and expression analysis of the putative interleukin 6 receptor (IL-6Rα and glycoprotein-130) in rainbow trout (Oncorhynchus mykiss): salmonid IL-6Rα possesses a polymorphic N-terminal Ig domain with variable numbers of twoCell type-specific differential induction of the human gamma-fibrinogen promoter by interleukin-6.The box-1 region of the leukemia inhibitory factor receptor alpha-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation.Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activationAn antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M.Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways.Activating mechanism of CNTF and related cytokines.gp130 transducing receptor cross-linking is sufficient to induce interleukin-6 type responses.STAT3 and STAT5B are targets of two different signal pathways activated by hematopoietin receptors and control transcription via separate cytokine response elements.The action of interleukin-2 receptor subunits defines a new type of signaling mechanism for hematopoietin receptors in hepatic cells and fibroblasts.Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signallingMolecular basis of the soluble and membrane-bound forms of the murine leukemia inhibitory factor receptor alpha-chain. Expression in normal, gestating, and leukemia inhibitory factor nullizygous mice.The cell surface expression level of the human interleukin-5 receptor alpha subunit determines the agonistic/antagonistic balance of the human interleukin-5 E13Q mutein.
P2860
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P2860
Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Multiple regions within the cy ...... in hepatic and neuronal cells
@ast
Multiple regions within the cy ...... in hepatic and neuronal cells
@en
Multiple regions within the cy ...... in hepatic and neuronal cells
@nl
type
label
Multiple regions within the cy ...... in hepatic and neuronal cells
@ast
Multiple regions within the cy ...... in hepatic and neuronal cells
@en
Multiple regions within the cy ...... in hepatic and neuronal cells
@nl
prefLabel
Multiple regions within the cy ...... in hepatic and neuronal cells
@ast
Multiple regions within the cy ...... in hepatic and neuronal cells
@en
Multiple regions within the cy ...... in hepatic and neuronal cells
@nl
P2093
P2860
P356
P1476
Multiple regions within the cy ...... in hepatic and neuronal cells
@en
P2093
D P Gearing
K K Morella
M R Comeau
S F Ziegler
P2860
P304
P356
10.1128/MCB.14.1.138
P407
P577
1994-01-01T00:00:00Z