Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway
about
Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's diseaseCaenorhabditis elegans as a model organism to study APP functionThe synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degenerationAmyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegenerationIntracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegansPresenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membraneTargeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: evidence for two distinct sorting steps.Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegans.Amyloid precursor protein is trafficked and secreted via synaptic vesiclesThe beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes.Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivoNumb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesisAmyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum.Sunday driver interacts with two distinct classes of axonal organelles.UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport.A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency.Neuronal activity and amyloid plaque pathology: an update.Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities.Amyloid precursor proteins are constituents of the presynaptic active zone.Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport.Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein.Accumulation of the amyloid-beta precursor protein in multivesicular body-like organelles.Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.Synapses in neurodegenerative diseases.APP processing is regulated by cytoplasmic phosphorylation.Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.Synaptic input as a directional cue for migrating interneuron precursors.Localization of endogenous amyloid-β to the coeruleo-cortical pathway: consequences of noradrenergic depletion.Organellar Omics-A Reviving Strategy to Untangle the Biomolecular Complexity of the Cell.ADAM10 and BACE1 are localized to synaptic vesicles.Analysis of differential gene expression supports a role for amyloid precursor protein and a protein kinase C substrate (MARCKS) in long-term memory.Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system.
P2860
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P2860
Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway
description
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1996
@ast
im Dezember 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/12/13)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/12/13)
@nl
наукова стаття, опублікована в грудні 1996
@uk
name
Alzheimer amyloid protein prec ...... n the synaptic vesicle pathway
@ast
Alzheimer amyloid protein prec ...... n the synaptic vesicle pathway
@en
Alzheimer amyloid protein prec ...... n the synaptic vesicle pathway
@nl
type
label
Alzheimer amyloid protein prec ...... n the synaptic vesicle pathway
@ast
Alzheimer amyloid protein prec ...... n the synaptic vesicle pathway
@en
Alzheimer amyloid protein prec ...... n the synaptic vesicle pathway
@nl
prefLabel
Alzheimer amyloid protein prec ...... n the synaptic vesicle pathway
@ast
Alzheimer amyloid protein prec ...... n the synaptic vesicle pathway
@en
Alzheimer amyloid protein prec ...... n the synaptic vesicle pathway
@nl
P2093
P2860
P356
P1476
Alzheimer amyloid protein prec ...... n the synaptic vesicle pathway
@en
P2093
A. F. Ikin
J. D. Buxbaum
P. De Camilli
W. G. Annaert
P2860
P304
31783–31786
P356
10.1074/JBC.271.50.31783
P407
P577
1996-12-13T00:00:00Z