Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling
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A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in plateletsVav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activationA crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activationSH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.Role of Src homology domain binding in signaling complexes assembled by the murid γ-herpesvirus M2 protein.Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering.Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells.Quantification of gel-separated proteins and their phosphorylation sites by LC-MS using unlabeled internal standards: analysis of phosphoprotein dynamics in a B cell lymphoma cell line.A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation.Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular storesHypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activationThe role of SH3BP2 in the pathophysiology of cherubism.Platelet GPIb-IX-V-dependent signaling.Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection.Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigenCalcium signalling and cell-fate choice in B cells.Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesisAutoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha.Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk.Assembly and Function of the Precursor B-Cell Receptor.A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.A novel Bruton's tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib impacts the bone microenvironment in a multiple myeloma model with resultant antimyeloma activity.Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity.Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase.Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases.Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines.Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling.Bruton's tyrosine kinase targets NF-kappaB to the bcl-x promoter via a mechanism involving phospholipase C-gamma2 following B cell antigen receptor engagement.Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signalingGlycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase.NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy.5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one (MSF-2) suppresses fMLP-mediated respiratory burst in human neutrophils by inhibiting phosphatidylinositol 3-kinase activity.
P2860
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P2860
Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling
description
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im Oktober 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/10/19)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/10/19)
@nl
наукова стаття, опублікована в жовтні 2001
@uk
name
Four tyrosine residues in phos ...... ptor-coupled calcium signaling
@ast
Four tyrosine residues in phos ...... ptor-coupled calcium signaling
@en
Four tyrosine residues in phos ...... ptor-coupled calcium signaling
@nl
type
label
Four tyrosine residues in phos ...... ptor-coupled calcium signaling
@ast
Four tyrosine residues in phos ...... ptor-coupled calcium signaling
@en
Four tyrosine residues in phos ...... ptor-coupled calcium signaling
@nl
prefLabel
Four tyrosine residues in phos ...... ptor-coupled calcium signaling
@ast
Four tyrosine residues in phos ...... ptor-coupled calcium signaling
@en
Four tyrosine residues in phos ...... ptor-coupled calcium signaling
@nl
P2093
P2860
P356
P1476
Four tyrosine residues in phos ...... ptor-coupled calcium signaling
@en
P2093
D. Watanabe
M. Matsushita
S. Hashimoto
S. Tsukada
T. Kishimoto
T. Kurosaki
P2860
P304
38595–38601
P356
10.1074/JBC.M103675200
P407
P577
2001-10-19T00:00:00Z