Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing
about
Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sortingHuntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neuronsActivation of the Sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astrogliaTargeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness.Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.Studies on the Q175 Knock-in Model of Huntington's Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory DysfunctionHuntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestineSortilin Fragments Deposit at Senile Plaques in Human CerebrumThe intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft traffickingTargeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept.Postnatal loss of hap1 reduces hippocampal neurogenesis and causes adult depressive-like behavior in mice.ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro.Role of adaptor proteins in secretory granule biogenesis and maturationSortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins.Multiple approaches to investigate the transport and activity-dependent release of BDNF and their application in neurogenetic disorders.Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells.Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.Investigation of Mature BDNF and proBDNF Signaling in a Rat Photothrombotic Ischemic Model.Morphine Withdrawal Increases Brain-Derived Neurotrophic Factor Precursor.HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons.Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior
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P2860
Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing
description
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
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artículu científicu espublizáu en 2011
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im Mai 2011 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2011/05/06)
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vědecký článek publikovaný v roce 2011
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wetenschappelijk artikel (gepubliceerd op 2011/05/06)
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наукова стаття, опублікована в травні 2011
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name
Precursor of brain-derived neu ...... g, degradation, and processing
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Precursor of brain-derived neu ...... g, degradation, and processing
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Precursor of brain-derived neu ...... g, degradation, and processing
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type
label
Precursor of brain-derived neu ...... g, degradation, and processing
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Precursor of brain-derived neu ...... g, degradation, and processing
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Precursor of brain-derived neu ...... g, degradation, and processing
@nl
prefLabel
Precursor of brain-derived neu ...... g, degradation, and processing
@ast
Precursor of brain-derived neu ...... g, degradation, and processing
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Precursor of brain-derived neu ...... g, degradation, and processing
@nl
P2093
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Precursor of brain-derived neu ...... g, degradation, and processing
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Jin-Hua Zhong
Xiaojiang Li
P2860
P304
16272–16284
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P356
10.1074/JBC.M110.195347
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P577
2011-05-06T00:00:00Z