An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo
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KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX.Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition.Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discriminationMutations in SLC12A5 in epilepsy of infancy with migrating focal seizures.A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formationWNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio)Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizuresCation-chloride cotransporters in neuronal development, plasticity and diseaseKCC2 activity is critical in limiting the onset and severity of status epilepticus.Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivoPrenatal Hypoxia-Ischemia Induces Abnormalities in CA3 Microstructure, Potassium Chloride Co-Transporter 2 Expression and Inhibitory Tone.K+-Cl- cotransporter-2 KCC2 in chicken cardiomyocytes.Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.Regional differences in the expression of K(+)-Cl(-) 2 cotransporter in the developing rat cortex.K-Cl cotransporter KCC2--a moonlighting protein in excitatory and inhibitory synapse development and function.The K(+)-Cl(-) Cotransporter KCC2 and Chloride Homeostasis: Potential Therapeutic Target in Acute Central Nervous System Injury.Chloride co-transporters as possible therapeutic targets for stroke.GABAergic Transmission during Brain Development: Multiple Effects at Multiple Stages.Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain.Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats.A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2The membrane trafficking and functionality of the K+-Cl- co-transporter KCC2 is regulated by TGF-β2.Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress.Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibitionDistribution of neuronal KCC2a and KCC2b isoforms in mouse CNS.Enhanced expression of potassium-chloride cotransporter KCC2 in human temporal lobe epilepsy.Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain.K+-Cl- co-transporter 2 (KCC2) - a membrane trafficking perspective.Emerging Mechanisms Underlying Dynamics of GABAergic Synapses.Development of inhibitory synaptic inputs on layer 2/3 pyramidal neurons in the rat medial prefrontal cortex.The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition.Nonsynaptic glycine release is involved in the early KCC2 expression.KCC2 Regulates Dendritic Spine Formation in a Brain-Region Specific and BDNF Dependent Manner
P2860
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P2860
An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo
description
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im Februar 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2013/02/01)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/02/01)
@nl
наукова стаття, опублікована в лютому 2013
@uk
مقالة علمية (نشرت في فبراير 2013)
@ar
name
An ion transport-independent r ...... dendritic spinogenesis in vivo
@ast
An ion transport-independent r ...... dendritic spinogenesis in vivo
@en
An ion transport-independent r ...... dendritic spinogenesis in vivo
@nl
type
label
An ion transport-independent r ...... dendritic spinogenesis in vivo
@ast
An ion transport-independent r ...... dendritic spinogenesis in vivo
@en
An ion transport-independent r ...... dendritic spinogenesis in vivo
@nl
prefLabel
An ion transport-independent r ...... dendritic spinogenesis in vivo
@ast
An ion transport-independent r ...... dendritic spinogenesis in vivo
@en
An ion transport-independent r ...... dendritic spinogenesis in vivo
@nl
P2093
P2860
P3181
P356
P1433
P1476
An ion transport-independent r ...... dendritic spinogenesis in vivo
@en
P2093
Adrian Briner
Alex G. Dayer
Bebyanda Jt Belem
Hubert Fiumelli
Jean-Luc Martin
Laszlo Vutskits
Martin Puskarjov
Peter Blaesse
P2860
P304
P3181
P356
10.1093/CERCOR/BHS027
P577
2013-02-01T00:00:00Z