Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase
about
Systematic identification of regulatory proteins critical for T-cell activationCAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cellsMolecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sitesThe role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signalingSH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinasePlatelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptorInteraction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kineticsMona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development.SH2-B is required for both male and female reproductionAPS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytesIdentification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signalingTyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cellsEnhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, LnkThe role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerLAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathwaysThe adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathwaysCharacterization of Lnk. An adaptor protein expressed in lymphocytesSLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cellsGlucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanismRegulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, LnkSignaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphataseSH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branchesIdentification of the APS protein as a novel insulin receptor substrateRegulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor proteinRole of the Lck Src homology 2 and 3 domains in protein tyrosine phosphorylation.p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cellsIdentification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related lociFour PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway.Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.The molecular regulation of Janus kinase (JAK) activationRecent advances in the genetics of systemic lupus erythematosus.SH2B1 regulation of energy balance, body weight, and glucose metabolism.SH2-B family members differentially regulate JAK family tyrosine kinases.Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing.Association Study of rs3184504 C>T Polymorphism in Patients With Coronary Artery Disease.Lnk adaptor: novel negative regulator of B cell lymphopoiesis.A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization.Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsetsLNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.
P2860
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P2860
Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase
description
1995 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1995
@ast
im Dezember 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/12/05)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/12/05)
@nl
наукова стаття, опублікована в грудні 1995
@uk
name
Cloning and characterization o ...... phosphatidylinositol 3-kinase
@ast
Cloning and characterization o ...... phosphatidylinositol 3-kinase
@en
Cloning and characterization o ...... phosphatidylinositol 3-kinase
@nl
type
label
Cloning and characterization o ...... phosphatidylinositol 3-kinase
@ast
Cloning and characterization o ...... phosphatidylinositol 3-kinase
@en
Cloning and characterization o ...... phosphatidylinositol 3-kinase
@nl
prefLabel
Cloning and characterization o ...... phosphatidylinositol 3-kinase
@ast
Cloning and characterization o ...... phosphatidylinositol 3-kinase
@en
Cloning and characterization o ...... phosphatidylinositol 3-kinase
@nl
P2093
P2860
P356
P1476
Cloning and characterization o ...... phosphatidylinositol 3-kinase
@en
P2093
P2860
P304
11618–11622
P356
10.1073/PNAS.92.25.11618
P407
P577
1995-12-05T00:00:00Z