Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation
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MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes researchRegulation of Bim in Health and DiseaseIslet inflammation: a unifying target for diabetes treatment?Interferons as inducers of apoptosis in malignant cellsIslet inflammation in plain sightToward beta cell replacement for diabetesGLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein BimEndoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalanceAbnormal Glucose Metabolism in Rheumatoid ArthritisSTAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions.The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cellsNova1 is a master regulator of alternative splicing in pancreatic beta cells.Caspase-3 is involved in IFN-γ- and TNF-α-mediated MIN6 cells apoptosis via NF-κB/Bcl-2 pathway.Oxidative stress and susceptibility to mitochondrial permeability transition precedes the onset of diabetes in autoimmune non-obese diabetic mice.STAT1-mediated down-regulation of Bcl-2 expression is involved in IFN-γ/TNF-α-induced apoptosis in NIT-1 cells.Apoptosis of human islet cells by cytokines.Prunella vulgaris aqueous extract attenuates IL-1β-induced apoptosis and NF-κB activation in INS-1 cells.C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells.USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosisEffects of interferons and double-stranded RNA on human prostate cancer cell apoptosis.Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and PathwaysImmune-mediated β-cell death in type 1 diabetes: lessons from human β-cell linesPathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Altered immune regulation in type 1 diabetes.LIGHT/IFN-γ triggers β cells apoptosis via NF-κB/Bcl2-dependent mitochondrial pathway.Inflammation and type one diabetes.Regulation of pancreatic β-cell survival by nitric oxide: clinical relevance.Diabetes in Friedreich ataxia.Targeting the pancreatic β-cell to treat diabetes.Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line.The JAK/STAT pathway in obesity and diabetes.Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development.Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia.Sumoylation Modulates the Susceptibility to Type 1 Diabetes.St. John's wort extract and hyperforin protect rat and human pancreatic islets against cytokine toxicity.Autophagy facilitates cytokine-induced ICAM-1 expression.Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling.14-3-3 proteins are essential signalling hubs for beta cell survival.The Potential Role of Krüppel-Like Zinc-Finger Protein Glis3 in Genetic Diseases and Cancers.Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected β cells.
P2860
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P2860
Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation
description
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2011
@ast
im November 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/11/11)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/11/11)
@nl
наукова стаття, опублікована в листопаді 2011
@uk
name
Cytokines tumor necrosis facto ...... ediated Bim protein activation
@ast
Cytokines tumor necrosis facto ...... ediated Bim protein activation
@en
Cytokines tumor necrosis facto ...... ediated Bim protein activation
@nl
type
label
Cytokines tumor necrosis facto ...... ediated Bim protein activation
@ast
Cytokines tumor necrosis facto ...... ediated Bim protein activation
@en
Cytokines tumor necrosis facto ...... ediated Bim protein activation
@nl
prefLabel
Cytokines tumor necrosis facto ...... ediated Bim protein activation
@ast
Cytokines tumor necrosis facto ...... ediated Bim protein activation
@en
Cytokines tumor necrosis facto ...... ediated Bim protein activation
@nl
P2093
P2860
P50
P3181
P356
P1476
Cytokines tumor necrosis facto ...... ediated Bim protein activation
@en
P2093
Adriano Maida
Andrea Jurisicova
Carla M. Germano
Conny Gysemans
Decio L. Eizirik
Esteban N. Gurzov
Fabrice Moore
Gabriel Nuñez
Jenny Barthson
P2860
P304
39632–39643
P3181
P356
10.1074/JBC.M111.253591
P407
P577
2011-11-11T00:00:00Z