STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
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MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes researchIslet inflammation in plain sightDiabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic InflammationIslet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetesGLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein BimSirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patientsEndoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalanceCytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activationPeripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell deathKinase-Independent Small-Molecule Inhibition of JAK-STAT SignalingJunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cellsThe human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in miceInduction of an inflammatory loop by interleukin-1β and tumor necrosis factor-α involves NF-kB and STAT-1 in differentiated human neuroprogenitor cells.Oxidative stress and redox modulation potential in type 1 diabetes.Influence of genes suppressing interferon effects in peripheral blood mononuclear cells during triple antiviral therapy for chronic hepatitis C.Clic4, a novel protein that sensitizes β-cells to apoptosisShort term exposure of beta cells to low concentrations of interleukin-1β improves insulin secretion through focal adhesion and actin remodeling and regulation of gene expression.Egg yolks inhibit activation of NF-κB and expression of its target genes in adipocytes after partial delipidation.STAT1-mediated down-regulation of Bcl-2 expression is involved in IFN-γ/TNF-α-induced apoptosis in NIT-1 cells.Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cellsUSP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosisProtective role of adenovirus vector-mediated interleukin-10 gene therapy on endogenous islet β-cells in recent-onset type 1 diabetes in NOD miceCytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and PathwaysSmall-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubilityUbiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta CellsGlucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation.Therapeutic properties of Scutellaria baicalensis in db/db mice evaluated using Connectivity Map and network pharmacology.Autophagy regulates inflammation following oxidative injury in diabetes.Suppressors of cytokine signaling (SOCS) and type 2 diabetes.Targeting the pancreatic β-cell to treat diabetes.The beta-cell in type 1 diabetes: What have we learned from proteomic studies?APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes.Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis.The JAK/STAT pathway in obesity and diabetes.Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms.
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P2860
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
description
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2011
@ast
im Januar 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/01/14)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/01/14)
@nl
наукова стаття, опублікована в січні 2011
@uk
name
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
@ast
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
@en
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
@nl
type
label
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
@ast
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
@en
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
@nl
prefLabel
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
@ast
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
@en
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
@nl
P2093
P2860
P50
P3181
P356
P1476
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation
@en
P2093
Decio L. Eizirik
Esteban N. Gurzov
Fabrice Moore
Maikel L. Colli
Mariana Igoillo-Esteve
Najib Naamane
Thomas Bouckenooghe
Thomas Thykjaer
Torben F. Ørntoft
P2860
P304
P3181
P356
10.1074/JBC.M110.162131
P407
P577
2011-01-14T00:00:00Z