PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways
about
Rap1 GTPases: an emerging role in the cardiovasculatureSoluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cellsUrocortin-1 Mediated Cardioprotection Involves XIAP and CD40-Ligand Recovery: Role of EPAC2 and ERK1/2Epac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytesProtein Kinases as Drug Development Targets for Heart Disease TherapyDifferential roles of Epac in regulating cell death in neuronal and myocardial cells.Dipyridamole with low-dose aspirin augments the infarct size-limiting effects of simvastatinT-type Ca²+ signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytesEPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.Roflumilast inhibits respiratory syncytial virus infection in human differentiated bronchial epithelial cellsCyclic AMP is both a pro-apoptotic and anti-apoptotic second messengerCyclic nucleotide signalling in kidney fibrosis.cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinasecAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of EpacThe Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytesInhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Targeting cancer with phosphodiesterase inhibitors.Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.Role of Epac in brain and heart.Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.Cardioprotection against experimental myocardial ischemic injury using cornin.A Role for cAMP and Protein Kinase A in Experimental Necrotizing Enterocolitis.Epac1 knockdown inhibits the proliferation of ovarian cancer cells by inactivating AKT/Cyclin D1/CDK4 pathway in vitro and in vivo.The role of Epac in the heart.Roflumilast: systemic therapy for chronic obstructive pulmonary disease.The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA.Roflumilast Ameliorates Airway Hyperresponsiveness Caused by Diet-Induced Obesity in a Murine Model.Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP+-induced decline of mitochondrial membrane potential and oxidative stress.The Phosphodiesterase 4 Inhibitor Roflumilast Protects against Cigarette Smoke Extract-Induced Mitophagy-Dependent Cell Death in Epithelial Cells.Suppression of soluble adenylyl cyclase protects smooth muscle cells against oxidative stress-induced apoptosis.Chemical-induced cardiac reprogramming in vivo.Ginseng Compatibility Environment Attenuates Toxicity and Keeps Efficacy in Cor Pulmonale Treated by Fuzi Beimu Incompatibility Through the Coordinated Crosstalk of PKA and Epac Signaling Pathways.Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke
P2860
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P2860
PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways
description
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Mai 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/05/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/05/01)
@nl
наукова стаття, опублікована в травні 2008
@uk
مقالة علمية (نشرت في مايو 2008)
@ar
name
PDE4 inhibitor, roflumilast pr ...... of PKA and Epac dual pathways
@ast
PDE4 inhibitor, roflumilast pr ...... of PKA and Epac dual pathways
@en
PDE4 inhibitor, roflumilast pr ...... of PKA and Epac dual pathways
@nl
type
label
PDE4 inhibitor, roflumilast pr ...... of PKA and Epac dual pathways
@ast
PDE4 inhibitor, roflumilast pr ...... of PKA and Epac dual pathways
@en
PDE4 inhibitor, roflumilast pr ...... of PKA and Epac dual pathways
@nl
prefLabel
PDE4 inhibitor, roflumilast pr ...... of PKA and Epac dual pathways
@ast
PDE4 inhibitor, roflumilast pr ...... of PKA and Epac dual pathways
@en
PDE4 inhibitor, roflumilast pr ...... of PKA and Epac dual pathways
@nl
P2093
P3181
P1433
P1476
PDE4 inhibitor, roflumilast pr ...... of PKA and Epac dual pathways
@en
P2093
Hye-Eun Choi
Hyun-Jeong Kwak
Hyun-Joung Lim
Hyun-Young Park
Kyoung-Mi Park
Kyung-Sook Chung
P304
P3181
P356
10.1016/J.CELLSIG.2007.12.011
P577
2008-05-01T00:00:00Z