The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.
about
Role of EPAC in cAMP-Mediated Actions in Adrenocortical CellsDynamics and molecular determinants of cytoplasmic lipid droplet clustering and dispersioncAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-productsRecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.Epac2-mediated dendritic spine remodeling: implications for disease.Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors.Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos.Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma modelβ-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent.5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.cAMP and EPAC are key players in the regulation of the signal transduction pathway involved in the α-hemolysin autophagic responseA role for Piezo2 in EPAC1-dependent mechanical allodynia.Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangementsEpac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent.Identification and characterization of small molecules as potent and specific EPAC2 antagonists.Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.Profilin isoforms modulate astrocytic morphology and the motility of astrocytic processesCyclic AMP is both a pro-apoptotic and anti-apoptotic second messengerProstaglandin E2 reduces the release and infectivity of new cell-free virions and cell-to-cell HIV-1 transfer.Epac activation initiates associative odor preference memories in the rat pup.The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.PDE4 regulates tissue plasminogen activator expression of human brain microvascular endothelial cellscAMP-mediated secretion of brain-derived neurotrophic factor in developing airway smooth muscle.Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth.cAMP and Epac in the regulation of tissue fibrosis.Epac activation sensitizes rat sensory neurons through activation of Ras.cAMP prevents TNF-induced apoptosis through inhibiting DISC complex formation in rat hepatocytesStructure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC AntagonistExchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppressionForskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.NPY Y1 receptors differentially modulate GABAA and NMDA receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons.Epac2 contributes to PACAP-induced astrocytic differentiation through calcium ion influx in neural precursor cellsRegulating the ubiquitin/proteasome pathway via cAMP-signaling: neuroprotective potentialSoluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor DifferentiationLuteoprotective mechanisms of prostaglandin F2α stimulated by luteinizing hormone in the bovine corpus luteum.Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells.
P2860
Q26744605-E3FEDF9F-D0F1-418A-AC36-D4F35DA10741Q27313632-0A4CBD32-CE31-487D-A9EF-5E0D9E18B407Q28587417-895BF87D-329C-4202-8359-D48121FA1063Q30405298-AE00CF35-8D1D-4DEA-8ABD-03E98E24F91DQ30433366-5D874400-0F56-4C77-B308-7C450E821A4AQ30471048-25795477-6E33-4FBD-84BD-FEBAE68D13FCQ31148493-4200EA57-7E4A-4CAE-A2F1-D42887094A50Q33840433-7401A651-1C3B-41C5-B7E3-FC3485CA8F93Q33964402-D4BE988D-9A5A-453B-A7D9-2FA174BD5BCDQ34044729-1B0B4BC1-68DC-478F-881B-E3DAD325FADAQ34274771-8DCB2027-8F28-4DE6-A75C-9906CA2C31C7Q34288762-F34B59B8-DD9E-4D7C-95F0-882300618904Q34338475-E5FD9A3F-EE76-46F9-BDCD-59620F92D439Q34356123-B73A7FE1-5DC7-40BE-B286-928AFCA2B5BBQ34356136-DCBE4D33-9F0F-433F-8EAC-67A38713669EQ34399575-6810783A-8976-481A-A4A8-EA1EDAF17EC4Q34421820-4B4DA1C0-8512-4BA7-AFD3-4B44BE2720F4Q34535973-D5130740-AF47-4A1D-8F8E-042731C704CCQ34715744-221E888E-3D9E-4D7C-AED4-2E1EA088BBD8Q35023628-3AAB6681-3A5A-4487-B430-0D808FCD82FFQ35074567-FCC1D385-D5BB-4229-B2CE-E77A2194B157Q35105850-5F5331AF-99B5-4F4A-A687-B23C1BAD3A56Q35123998-369E14F8-3CD5-49C6-9F00-F1D220357DC5Q35743330-F39AE92F-6356-4EF2-B7F6-1D1DDE4643B4Q35985145-E8E79B36-12FE-4E29-B118-A4B648CC21B7Q36021241-74B10D1C-306A-43CC-A115-12B2D91052D1Q36024175-A7537A13-A1CC-43CF-8B94-CE513BCEE78FQ36159130-FECE4D4B-F956-49EE-903B-960923AA7513Q36421321-0DDA2F63-6910-46A1-A0D3-2BBF8BE82A78Q36620940-72464C4C-C380-4704-8E8E-622C9E1B6E2AQ36624204-08E26D2E-C29F-4549-94C6-5EA984BADED3Q36634333-21BC20D1-7910-47E5-8098-B93466F562E3Q36635113-0F8AAA2D-57B0-42F6-919D-A52286920205Q36666221-8CEC98AA-35BC-4EA5-ABAE-21FDF1A5BA25Q36850591-765FF597-4193-4182-9F83-DA0F52F6BB5AQ37024472-95A5F9F1-49B0-42DB-8257-7A2227E76883Q37136291-AA8B7109-8BC7-41AC-8D68-00ADB4C27CC5Q37316161-E811FFB6-8C7E-4614-918E-F29F54CD3715Q37602091-124C30FC-4038-4D80-A57E-381FB41EC392Q37683308-C56878FA-010F-409B-A61A-FBBD1920977A
P2860
The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
The role of Epac proteins, nov ...... e, lung and neuronal function.
@en
The role of Epac proteins, nov ...... e, lung and neuronal function.
@nl
type
label
The role of Epac proteins, nov ...... e, lung and neuronal function.
@en
The role of Epac proteins, nov ...... e, lung and neuronal function.
@nl
prefLabel
The role of Epac proteins, nov ...... e, lung and neuronal function.
@en
The role of Epac proteins, nov ...... e, lung and neuronal function.
@nl
P2093
P2860
P1476
The role of Epac proteins, nov ...... e, lung and neuronal function.
@en
P2093
Maria Grandoch
Martina Schmidt
Sara S Roscioni
P2860
P304
P356
10.1111/J.1476-5381.2009.00458.X
P407
P577
2009-11-11T00:00:00Z