Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
about
The mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependenceDistinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor traffickingActivation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross-talkβ-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A.β-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons.Angiotensin II induces membrane trafficking of natively expressed transient receptor potential vanilloid type 4 channels in hypothalamic 4B cellsFunctional competence of a partially engaged GPCR-β-arrestin complexβ-Arrestin-mediated receptor trafficking and signal transductionEmerging paradigms of β-arrestin-dependent seven transmembrane receptor signalingAnalgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels.Ubiquitin-mediated regulation of endocytosis by proteins of the arrestin family.Characterization of blood pressure and endothelial function in TRPV4-deficient mice with l-NAME- and angiotensin II-induced hypertension.Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking.Cell signaling of angiotensin II on vascular tone: novel mechanisms.Functional relevance of biased signaling at the angiotensin II type 1 receptor.G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.The thermo-TRP ion channel family: properties and therapeutic implications.Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease.TRPV4: physiological role and therapeutic potential in respiratory diseases.The E3 ligase Itch in immune regulation and beyond.Ubiquitin-Related Roles of β-Arrestins in Endocytic Trafficking and Signal Transduction.Hypotonicity-induced TRPV4 function in renal collecting duct cells: modulation by progressive cross-talk with Ca2+-activated K+ channelsProlonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes.Differential ubiquitination and proteasome regulation of Ca(V)2.2 N-type channel splice isoforms.TRPV1 is a physiological regulator of μ-opioid receptors.Human podocytes express functional thermosensitive TRPV channels.A New Mutation in FIG4 Causes a Severe Form of CMT4J Involving TRPV4 in the Pathogenic Cascade.Role of proNGF/p75 signaling in bladder dysfunction after spinal cord injury.Phosphorylation regulates TRPV1 association with β-arrestin-2.Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.
P2860
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P2860
Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
description
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2010
@ast
im September 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/09/24)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/09/24)
@nl
наукова стаття, опублікована у вересні 2010
@uk
name
Arresting a transient receptor ...... ional down-regulation of TRPV4
@ast
Arresting a transient receptor ...... ional down-regulation of TRPV4
@en
Arresting a transient receptor ...... ional down-regulation of TRPV4
@nl
type
label
Arresting a transient receptor ...... ional down-regulation of TRPV4
@ast
Arresting a transient receptor ...... ional down-regulation of TRPV4
@en
Arresting a transient receptor ...... ional down-regulation of TRPV4
@nl
prefLabel
Arresting a transient receptor ...... ional down-regulation of TRPV4
@ast
Arresting a transient receptor ...... ional down-regulation of TRPV4
@en
Arresting a transient receptor ...... ional down-regulation of TRPV4
@nl
P2093
P2860
P3181
P356
P1476
Arresting a transient receptor ...... ional down-regulation of TRPV4
@en
P2093
Kunhong Xiao
Robert J Lefkowitz
Seungkirl Ahn
Sudha K Shenoy
Wolfgang Liedtke
P2860
P304
30115-30125
P3181
P356
10.1074/JBC.M110.141549
P407
P577
2010-07-22T00:00:00Z