Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion
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MicroRNAs as pharmacological targets in diabetesIntracellular Theileria annulata promote invasive cell motility through kinase regulation of the host actin cytoskeletonMAP4K4: an emerging therapeutic target in cancerAn islet in distress: β cell failure in type 2 diabetes.The macrophage A2B adenosine receptor regulates tissue insulin sensitivityMAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance.Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cellsHGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistanceThe A2b adenosine receptor modulates glucose homeostasis and obesityFractalkine (CX3CL1), a new factor protecting β-cells against TNFαAssociation of common genetic variants in the MAP4K4 locus with prediabetic traits in humans.Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscleFocal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin.Type 2 Diabetes Mellitus-Induced Hyperglycemia in Patients with NAFLD and Normal LFTs: Relationship to Lipid Profile, Oxidative Stress and Pro-Inflammatory Cytokines.Cytochrome P450 1B1: An unexpected modulator of liver fatty acid homeostasisAnthrax lethal toxin suppresses high glucose induced VEGF over secretion through a post-translational mechanism.MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells.Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosisAssociation of Common Genetic Variants in Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 with Type 2 Diabetes Mellitus in a Chinese Han Population.Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.Targeting kinases for the treatment of inflammatory diseases.Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease.TNFα-induced DLK activation contributes to apoptosis in the beta-cell line HIT.SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells.Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells.Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4.Association of MAP4K4 gene single nucleotide polymorphism with mastitis and milk traits in Chinese Holstein cattle.
P2860
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P2860
Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion
description
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2009
@ast
im Oktober 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/10/09)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/10/09)
@nl
наукова стаття, опублікована в жовтні 2009
@uk
name
Silencing mitogen-activated pr ...... e-stimulated insulin secretion
@ast
Silencing mitogen-activated pr ...... e-stimulated insulin secretion
@en
Silencing mitogen-activated pr ...... e-stimulated insulin secretion
@nl
type
label
Silencing mitogen-activated pr ...... e-stimulated insulin secretion
@ast
Silencing mitogen-activated pr ...... e-stimulated insulin secretion
@en
Silencing mitogen-activated pr ...... e-stimulated insulin secretion
@nl
prefLabel
Silencing mitogen-activated pr ...... e-stimulated insulin secretion
@ast
Silencing mitogen-activated pr ...... e-stimulated insulin secretion
@en
Silencing mitogen-activated pr ...... e-stimulated insulin secretion
@nl
P2093
P2860
P3181
P356
P1476
Silencing mitogen-activated pr ...... e-stimulated insulin secretion
@en
P2093
Karim Bouzakri
Pascale Ribaux
Philippe A. Halban
P2860
P304
27892–27898
P3181
P356
10.1074/JBC.M109.048058
P407
P577
2009-10-09T00:00:00Z