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Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytesActivation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses53BP2S, interacting with insulin receptor substrates, modulates insulin signalingPhosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cellsUpregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiaInsulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathyThe differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptorIRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosisDysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetesRecent advances in understanding the anti-diabetic actions of dietary flavonoidsJunctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose toleranceDisruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetesRole of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models.Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB betaSignal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylationInsulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeMechanisms of action of glucagon-like peptide 1 in the pancreasGlycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeuticsNovel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationStearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscleEssential role of Gab1 for signaling by the c-Met receptor in vivoInsulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic DisordersSuppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-CellsMolecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of FlavonoidsAsparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)Insulin receptor signaling in normal and insulin-resistant statesThe required beta cell research for improving treatment of type 2 diabetesCalcineurin inhibition and new-onset diabetes mellitus after transplantationRole of AKT/mTORC1 pathway in pancreatic β-cell proliferationAnimal models of diabetes mellitus for islet transplantationPost-transcriptional regulation in metabolic diseasesInsulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liverHepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3Involvement of the PA28 -Dependent Pathway in Insulin Resistance Induced by Hepatitis C Virus Core ProteinBinding of AR-1-144, a tri-imidazole DNA minor groove binder, to CCGG sequence analyzed by NMR spectroscopyPresent status of clinical deployment of glucokinase activatorsLongevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intakeThe Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated ProteinsShc and CEACAM1 interact to regulate the mitogenic action of insulinThrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes
P2860
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P2860
description
1998 nî lūn-bûn
@nan
1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Disruption of IRS-2 causes type 2 diabetes in mice
@ast
Disruption of IRS-2 causes type 2 diabetes in mice
@en
Disruption of IRS-2 causes type 2 diabetes in mice
@en-gb
Disruption of IRS-2 causes type 2 diabetes in mice
@nl
type
label
Disruption of IRS-2 causes type 2 diabetes in mice
@ast
Disruption of IRS-2 causes type 2 diabetes in mice
@en
Disruption of IRS-2 causes type 2 diabetes in mice
@en-gb
Disruption of IRS-2 causes type 2 diabetes in mice
@nl
prefLabel
Disruption of IRS-2 causes type 2 diabetes in mice
@ast
Disruption of IRS-2 causes type 2 diabetes in mice
@en
Disruption of IRS-2 causes type 2 diabetes in mice
@en-gb
Disruption of IRS-2 causes type 2 diabetes in mice
@nl
P2093
P921
P3181
P356
P1433
P1476
Disruption of IRS-2 causes type 2 diabetes in mice
@en
P2093
D J Withers
J S Gutierrez
S Bonner-Weir
P2888
P304
P3181
P356
10.1038/36116
P407
P577
1998-02-01T00:00:00Z
P5875
P6179
1019591506