Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome traffic
about
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαThe schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapseClathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cellsThe crystal structure of the phosphatidylinositol 4-kinase IIαPhosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase ItchSPE-39 family proteins interact with the HOPS complex and function in lysosomal deliveryVps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomesPhosphoinositides: tiny lipids with giant impact on cell regulationPtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes.Structural Basis of the Intracellular Sorting of the SNARE VAMP7 by the AP3 Adaptor ComplexThe high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor designGenome-wide analysis of AP-3-dependent protein transport in yeastPhosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platformsCinderella story: PI4P goes from precursor to key signaling moleculeHermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampusRoles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesiclesDifferential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 ActivityCalcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axonsType II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in DrosophilaChemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis.SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking.Endosomal recycling regulates Anthrax Toxin Receptor 1/Tumor Endothelial Marker 8-dependent cell spreading.An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet beta-cells.Isolation of labile multi-protein complexes by in vivo controlled cellular cross-linking and immuno-magnetic affinity chromatographyPI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation.Endosomal sorting of VAMP3 is regulated by PI4K2A.Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase.Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIα.Palmitoylation controls the catalytic activity and subcellular distribution of phosphatidylinositol 4-kinase II{alpha}Phosphoinositide signaling: new tools and insights.Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network.Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis.Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network.Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes.Molecular brightness analysis reveals phosphatidylinositol 4-Kinase IIβ association with clathrin-coated vesicles in living cells.Notch signaling from the endosome requires a conserved dileucine motif.
P2860
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P2860
Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome traffic
description
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im April 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/04/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/04/01)
@nl
наукова стаття, опублікована у квітні 2008
@uk
مقالة علمية (نشرت في أبريل 2008)
@ar
name
Phosphatidylinositol-4-kinase ...... required for endosome traffic
@ast
Phosphatidylinositol-4-kinase ...... required for endosome traffic
@en
Phosphatidylinositol-4-kinase ...... required for endosome traffic
@nl
type
label
Phosphatidylinositol-4-kinase ...... required for endosome traffic
@ast
Phosphatidylinositol-4-kinase ...... required for endosome traffic
@en
Phosphatidylinositol-4-kinase ...... required for endosome traffic
@nl
prefLabel
Phosphatidylinositol-4-kinase ...... required for endosome traffic
@ast
Phosphatidylinositol-4-kinase ...... required for endosome traffic
@en
Phosphatidylinositol-4-kinase ...... required for endosome traffic
@nl
P2860
P3181
P356
P1476
Phosphatidylinositol-4-kinase ...... required for endosome traffic
@en
P2093
Branch Craige
Gloria Salazar
P2860
P304
P3181
P356
10.1091/MBC.E07-12-1239
P577
2008-04-01T00:00:00Z