Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
about
Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcriptionEpigenetics: a molecular link between environmental factors and type 2 diabetesThe PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoterPdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylationMechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription.Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinasesTranscriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.PDX-1 interaction and regulation of the Pancreatic Derived Factor (PANDER, FAM3B) promoter.The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription.Transgenic expression of insulin-response element binding protein-1 in beta-cells reproduces type 2 diabetesMODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cellsEnvironmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function.Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.Histone modifications: Targeting head and neck cancer stem cells.Regulation of pancreas duodenum homeobox-1 expression by early growth response-1.Amino acid 1-209 is essential for PDX-1-mediated repression of human CMV IE promoter activity.Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms.Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c).Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis.Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment.
P2860
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P2860
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
description
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Juni 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/06/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/06/01)
@nl
наукова стаття, опублікована в червні 2004
@uk
مقالة علمية (نشرت في يونيو 2004)
@ar
name
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
@ast
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
@en
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
@nl
type
label
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
@ast
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
@en
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
@nl
prefLabel
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
@ast
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
@en
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
@nl
P2093
P356
P1433
P1476
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
@en
P2093
Joel F. Habener
Melissa K. Thomas
Violeta Stanojevic
P304
P356
10.1210/EN.2003-1188
P407
P577
2004-06-01T00:00:00Z