Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis. - Wikidata - wikimedia - TriplyDB

Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis.

Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis.

http://www.wikidata.org/entity/Q45161628

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Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice RB regulates pancreas development by stabilizing Pdx1 Glucose-dependent blood flow dynamics in murine pancreatic islets in vivo.Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases AGEs decrease insulin synthesis in pancreatic β-cell by repressing Pdx-1 protein expression at the post-translational level.Revealing transcription factors during human pancreatic β cell development.Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice.Neonatal exendin-4 reduces growth, fat deposition and glucose tolerance during treatment in the intrauterine growth-restricted lamb.Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.Effects of genetics and in utero diet on murine pancreatic development.Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass.Functionalized self-assembling peptide improves INS-1 β-cell function and proliferation via the integrin/FAK/ERK/cyclin pathway Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat.A simple matter of life and death-the trials of postnatal Beta-cell mass regulation Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas.Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB.Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretion In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter.Peroxisome proliferator-activated receptor γ (PPARγ) and its target genes are downstream effectors of FoxO1 protein in islet β-cells: mechanism of β-cell compensation and failure.Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion On the origin of the beta cell.Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation.Pancreatic islet vasculature adapts to insulin resistance through dilation and not angiogenesis.Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.Epigenetic changes in diabetes.Beta cell dynamics: beta cell replenishment, beta cell compensation and diabetes.Treatment of metabolic syndrome with ankaflavin, a secondary metabolite isolated from the edible fungus Monascus spp.Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes.Beta cell dysfunction and insulin resistance Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats.A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes.The levels of Pdx1/insulin, Cacna1c and Cacna1d, and β-cell mass in a rat model of intrauterine undernutrition.Conditional β1-integrin-deficient mice display impaired pancreatic β cell function.Testing the plasticity of insulin secretion and β-cell functionin vivo: responses to chronic hyperglycaemia in the sheep

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P2860

Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis.

http://www.wikidata.org/entity/Q45161628

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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name

Reduced PDX-1 expression impai ...... d worsens glucose homeostasis.

@en

Reduced PDX-1 expression impai ...... d worsens glucose homeostasis.

@nl

type

label

Reduced PDX-1 expression impai ...... d worsens glucose homeostasis.

@en

Reduced PDX-1 expression impai ...... d worsens glucose homeostasis.

@nl

prefLabel

Reduced PDX-1 expression impai ...... d worsens glucose homeostasis.

@en

Reduced PDX-1 expression impai ...... d worsens glucose homeostasis.

@nl

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AJPENDO.00252.2004

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American Journal of Physiology - Endocrinology and Metabolism

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Reduced PDX-1 expression impai ...... d worsens glucose homeostasis.

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P2093

Alvin C Powers

http://www.w3.org/2001/XMLSchema#string

Aramandla Radhika

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Cathi Spear

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Christopher V E Wright

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Marcela Brissova

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Masakazu Shiota

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Maureen J Charron

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Michael Blaha

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Wendell Nicholson

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P2860

Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

Increased islet apoptosis in Pdx1+/- mice

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets

Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

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10.1152/AJPENDO.00252.2004

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4

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288

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2004-11-23T00:00:00Z

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8165621

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