Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
about
Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humansJanus kinases in immune cell signalingJanus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancerJAK and MPL mutations in myeloid malignancies.Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis.The molecular regulation of Janus kinase (JAK) activationLoss of wild-type Jak2 allele enhances myeloid cell expansion and accelerates myelofibrosis in Jak2V617F knock-in micec-Abl activates janus kinase 2 in normal hematopoietic cells.Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.Jak2 is necessary for neuroendocrine control of female reproductionVascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.The two faces of Janus kinases and their respective STATs in mammary gland development and cancerHepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.Manganese superoxide dismutase is dispensable for post-natal development and lactation in the murine mammary glandG-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote CancerProlactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiationJanus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.JAK-STAT and bone metabolismTargeting janus kinase 2 in Her2/neu-expressing mammary cancer: Implications for cancer prevention and therapy.Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistanceImproved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms.Sensitivity and resistance of JAK2 inhibitors to myeloproliferative neoplasms.Selective JAK inhibitors.JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice.Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing.Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia.Essential functions of the Janus kinase 2 (Jak2) during mammary gland development and tumorigenesis.Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation.Generation of Janus kinase 1 (JAK1) conditional knockout mice.Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes.Involvement of genes related to inflammation and cell cycle in idiopathic short stature.
P2860
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P2860
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
description
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im September 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/09/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/09/01)
@nl
наукова стаття, опублікована у вересні 2004
@uk
مقالة علمية (نشرت في سبتمبر 2004)
@ar
name
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
@ast
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
@en
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
@nl
type
label
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
@ast
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
@en
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
@nl
prefLabel
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
@ast
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
@en
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
@nl
P2093
P3181
P356
P1433
P1476
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
@en
P2093
Aleata A. Triplett
Andrea Krempler
Hallgeir Rui
Jianqiong Zhu
Kay-Uwe Wagner
Yongyue Qi
P3181
P356
10.1002/GENE.20063
P577
2004-09-01T00:00:00Z