A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.
about
Nix is a selective autophagy receptor for mitochondrial clearanceRibosome-based quality control of mRNA and nascent peptidesRibosome-associated protein quality controlThe Not4 RING E3 Ligase: A Relevant Player in Cotranslational Quality ControlA ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stressAsc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats.Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation.Role of a ribosome-associated E3 ubiquitin ligase in protein quality controlCdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociationProfile of Steve Kay.Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation.The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factorsStructural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex.A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice.ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice.Ubiquitination of newly synthesized proteins at the ribosome.The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.Rkr1/Ltn1 Ubiquitin Ligase-mediated Degradation of Translationally Stalled Endoplasmic Reticulum Proteins.TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elementsA Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission YeastDegradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in YeastA network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast.The Paf1 complex subunit Rtf1 buffers cells against the toxic effects of [PSI+] and defects in Rkr1-dependent protein quality control in Saccharomyces cerevisiae.Single-particle EM reveals extensive conformational variability of the Ltn1 E3 ligase.The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells.Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunitsDistinct types of translation termination generate substrates for ribosome-associated quality control.Regulation of stem cell function by protein ubiquitylationUbiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagyMitochondrial quality control and neurological disease: an emerging connection.Misfolded proteins recognition strategies of E3 ubiquitin ligases and neurodegenerative diseases.The ribosome as a hub for protein quality control.Co-translational mechanisms of quality control of newly synthesized polypeptides.Proteome complexity and the forces that drive proteome imbalance.Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins.The ribosome-bound quality control complex: from aberrant peptide clearance to proteostasis maintenance.Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex.
P2860
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P2860
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A mouse forward genetics scree ...... involved in neurodegeneration
@nl
A mouse forward genetics scree ...... involved in neurodegeneration.
@ast
A mouse forward genetics scree ...... involved in neurodegeneration.
@en
type
label
A mouse forward genetics scree ...... involved in neurodegeneration
@nl
A mouse forward genetics scree ...... involved in neurodegeneration.
@ast
A mouse forward genetics scree ...... involved in neurodegeneration.
@en
prefLabel
A mouse forward genetics scree ...... involved in neurodegeneration
@nl
A mouse forward genetics scree ...... involved in neurodegeneration.
@ast
A mouse forward genetics scree ...... involved in neurodegeneration.
@en
P2093
P2860
P3181
P356
P1476
A mouse forward genetics scree ...... involved in neurodegeneration.
@en
P2093
Brian V Jenkins
Christopher C Goodnow
Claudio A Masuda
Claudio A P Joazeiro
Jessie Chu
Keats A Nelms
Nancy A Hong
Richard J Glynne
Steve A Kay
P2860
P304
P3181
P356
10.1073/PNAS.0812819106
P407
P577
2009-02-05T00:00:00Z