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Phosphorylation of NLRC4 is critical for inflammasome activation

Phosphorylation of NLRC4 is critical for inflammasome activation

http://www.wikidata.org/entity/Q28586109

about

The NAIP/NLRC4 inflammasomes Of inflammasomes and pathogens--sensing of microbes by the inflammasome Inflammasomes: mechanism of action, role in disease, and therapeutics Mechanisms of inflammasome activation: recent advances and novel insights Pyroptotic cell death defends against intracellular pathogens Policing the cytosol--bacterial-sensing inflammasome receptors and pathways Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.Crystal structure of NLRC4 reveals its autoinhibition mechanism International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease Initiation and perpetuation of NLRP3 inflammasome activation and assembly Structural mechanisms of inflammasome assembly The nucleotide-binding oligomerization domain-containing protein 1 (NOD1) polymorphism S7N does not affect receptor function Activation and regulation of the inflammasomes Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases.A time-resolved molecular map of the macrophage response to VSV infection Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease Caspase-1: the inflammasome and beyond.Inflammasomes as polyvalent cell death platforms.The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation.Structural mechanisms in NLR inflammasome signaling.ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity.Nedd8 regulates inflammasome-dependent caspase-1 activation.Inflammasomes.3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5 Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.Regulation of inflammasome activation.PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection.Mechanisms and pathways of innate immune activation and regulation in health and cancer.Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity.

P2860

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P2860

Phosphorylation of NLRC4 is critical for inflammasome activation

http://www.wikidata.org/entity/Q28586109

description

2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

article publié dans la revue scientifique Nature

@fr

artículu científicu espublizáu en 2012

@ast

scientific journal article

@en

vedecký článok (publikovaný 2012/10/25)

@sk

vědecký článek publikovaný v roce 2012

@cs

wetenschappelijk artikel (gepubliceerd op 2012/10/25)

@nl

наукова стаття, опублікована в жовтні 2012

@uk

مقالة علمية (نشرت في 25-10-2012)

@ar

name

Phosphorylation of NLRC4 is critical for inflammasome activation

@ast

Phosphorylation of NLRC4 is critical for inflammasome activation

@en

Phosphorylation of NLRC4 is critical for inflammasome activation

@nl

type

label

Phosphorylation of NLRC4 is critical for inflammasome activation

@ast

Phosphorylation of NLRC4 is critical for inflammasome activation

@en

Phosphorylation of NLRC4 is critical for inflammasome activation

@nl

prefLabel

Phosphorylation of NLRC4 is critical for inflammasome activation

@ast

Phosphorylation of NLRC4 is critical for inflammasome activation

@en

Phosphorylation of NLRC4 is critical for inflammasome activation

@nl

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Phosphorylation of NLRC4 is critical for inflammasome activation

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Anita Izrael-Tomasevic

http://www.w3.org/2001/XMLSchema#string

David Arnott

http://www.w3.org/2001/XMLSchema#string

Denise Monack

http://www.w3.org/2001/XMLSchema#string

James E. Cupp

http://www.w3.org/2001/XMLSchema#string

Kim Newton

http://www.w3.org/2001/XMLSchema#string

Laurie L. Gilmour

http://www.w3.org/2001/XMLSchema#string

László Kömüves

http://www.w3.org/2001/XMLSchema#string

Mohamed Lamkanfi

http://www.w3.org/2001/XMLSchema#string

Nobuhiko Kayagaki

http://www.w3.org/2001/XMLSchema#string

Salina Louie

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Cryopyrin activates the inflammasome in response to toxins and ATP

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

P2888

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539–542

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scholarly article

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3121124

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10.1038/NATURE11429

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1020499503

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Protein kinase C, delta

NLR family, CARD domain containing 4

phosphorylation