Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes
about
Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidaseRegulation of the cardiac sodium pumpNa+/Ca2+ exchange and Na+/K+-ATPase in the heartAgrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contractionA separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscleNitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanismPhospholemman deficiency in postinfarct hearts: enhanced contractility but increased mortality.Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase.Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman.Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during beta-adrenergic stimulation in mouse ventricular myocytes.Regulation of cardiac myocyte contractility by phospholemman: Na+/Ca2+ exchange versus Na+ -K+ -ATPasePhospholemman: a novel cardiac stress protein.Phosphomimetic mutations enhance oligomerization of phospholemman and modulate its interaction with the Na/K-ATPase.Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes.Residues 248-252 and 300-304 of the cardiac Na+/Ca2+ exchanger are involved in its regulation by phospholemman.The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation.Phospholemman expression is high in the newborn rabbit heart and declines with postnatal maturationIntracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells.Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interactionAgonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.Phospholemman regulates cardiac Na+/Ca2+ exchanger by interacting with the exchanger's proximal linker domainFXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C.Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes.Effects of PKA phosphorylation on the conformation of the Na,K-ATPase regulatory protein FXYD1.Isoform specificity of the Na/K-ATPase association and regulation by phospholemman.Regulation of cardiac excitability by protein kinase C isozymes.Redox control of cardiac excitability.A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases.Limitations in intense exercise performance of athletes - effect of speed endurance training on ion handling and fatigue development.Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPaseMaternal dietary supplementation with saturated, but not monounsaturated or polyunsaturated fatty acids, leads to tissue-specific inhibition of offspring Na+,K+-ATPase.Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport.Phosphorylation of phospholemman (FXYD1) by protein kinases A and C modulates distinct Na,K-ATPase isozymes.Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity.Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia.
P2860
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P2860
Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes
description
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im November 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/12/08)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/12/08)
@nl
наукова стаття, опублікована в грудні 2006
@uk
مقالة علمية (نشرت في 8-12-2006)
@ar
name
Phospholemman phosphorylation ...... p function in cardiac myocytes
@ast
Phospholemman phosphorylation ...... p function in cardiac myocytes
@en
Phospholemman phosphorylation ...... p function in cardiac myocytes
@nl
type
label
Phospholemman phosphorylation ...... p function in cardiac myocytes
@ast
Phospholemman phosphorylation ...... p function in cardiac myocytes
@en
Phospholemman phosphorylation ...... p function in cardiac myocytes
@nl
prefLabel
Phospholemman phosphorylation ...... p function in cardiac myocytes
@ast
Phospholemman phosphorylation ...... p function in cardiac myocytes
@en
Phospholemman phosphorylation ...... p function in cardiac myocytes
@nl
P2093
P921
P3181
P1433
P1476
Phospholemman phosphorylation ...... p function in cardiac myocytes
@en
P2093
Amy L Tucker
Julie Bossuyt
Sanda Despa
P304
P3181
P356
10.1161/01.RES.0000251667.73461.FB
P577
2006-11-09T00:00:00Z