Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone
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Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoproteinASARM peptides: PHEX-dependent and -independent regulation of serum phosphateDegradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYPExtracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemiaRegulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathwayFGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralizationHomozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient miceRole of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemiaMatrix extracellular phosphoglycoprotein inhibits phosphate transportTargeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone massMEPE is a novel regulator of growth plate cartilage mineralizationAbnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin.Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator.MEPE/OF45 as a new target for sensitizing human tumour cells to DNA damage inducersMepe is expressed during skeletal development and regeneration.A small peptide mimicking the key domain of MEPE/OF45 interacting with CHK1 protects human cells from radiation-induced killing.A Novel PHEX Gene Mutation in a Patient with Sporadic Hypophosphatemic Rickets.Adaptive evolution of the matrix extracellular phosphoglycoprotein in mammalsMEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21.Surface immobilization of MEPE peptide onto HA/β-TCP ceramic particles enhances bone regeneration and remodeling.Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp miceExpression and processing of small integrin-binding ligand N-linked glycoproteins in mouse odontoblastic cells.MEPE-derived ASARM peptide inhibits odontogenic differentiation of dental pulp stem cells and impairs mineralization in tooth models of X-linked hypophosphatemiaMEPE expression in osteocytes during orthodontic tooth movementThe wrickkened pathways of FGF23, MEPE and PHEX.Phosphate: known and potential roles during development and regeneration of teeth and supporting structures.Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets.Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activityCorrection of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatinSclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism.Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled.Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia.Emerging role of a phosphatonin in mineral homeostasis and its derangements.Radiation activated CHK1/MEPE pathway may contribute to microgravity-induced bone density loss.MicroRNA-376a sensitizes cells following DNA damage by downregulating MEPE expression.Molecular regulation of matrix extracellular phosphoglycoprotein expression by bone morphogenetic protein-2MEPE/OF45 protects cells from DNA damage induced killing via stabilizing CHK1.Kidney and phosphate metabolism.Hypophosphatemia and growth.
P2860
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P2860
Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone
description
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Juni 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/06/15)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/06/15)
@nl
наукова стаття, опублікована в червні 2001
@uk
مقالة علمية (نشرت في 15-6-2001)
@ar
name
Mepe, the gene encoding a tumo ...... omalacia, is expressed in bone
@ast
Mepe, the gene encoding a tumo ...... omalacia, is expressed in bone
@en
Mepe, the gene encoding a tumo ...... omalacia, is expressed in bone
@nl
type
label
Mepe, the gene encoding a tumo ...... omalacia, is expressed in bone
@ast
Mepe, the gene encoding a tumo ...... omalacia, is expressed in bone
@en
Mepe, the gene encoding a tumo ...... omalacia, is expressed in bone
@nl
prefLabel
Mepe, the gene encoding a tumo ...... omalacia, is expressed in bone
@ast
Mepe, the gene encoding a tumo ...... omalacia, is expressed in bone
@en
Mepe, the gene encoding a tumo ...... omalacia, is expressed in bone
@nl
P2093
P356
P1433
P1476
Mepe, the gene encoding a tumo ...... omalacia, is expressed in bone
@en
P2093
F. H. Glorieux
M. Desbarats
P304
P356
10.1006/GENO.2001.6553
P577
2001-06-15T00:00:00Z