Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

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http://www.wikidata.org/entity/Q35975746

Q35975746

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ASARM peptides: PHEX-dependent and -independent regulation of serum phosphate Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP Regulation and function of the FGF23/klotho endocrine pathways Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease Extracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemia Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway Recent advances in the renal-skeletal-gut axis that controls phosphate homeostasis Matrix extracellular phosphoglycoprotein inhibits phosphate transport MEPE is a novel regulator of growth plate cartilage mineralization PHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolism Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator.Bone mineral density and serum biochemical predictors of bone loss in patients with CKD on dialysis.MEPE-derived ASARM peptide inhibits odontogenic differentiation of dental pulp stem cells and impairs mineralization in tooth models of X-linked hypophosphatemia Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling.The impairment of osteogenesis in bone sialoprotein (BSP) knockout calvaria cell cultures is cell density dependent.ASARM mineralization hypothesis: a bridge too far?Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: identification as an allele of 'Hyp'.Biomineralization of bone: a fresh view of the roles of non-collagenous proteins.The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled.High Parathyroid Hormone Level and Osteoporosis Predict Progression of Coronary Artery Calcification in Patients on Dialysis.Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice.Family with sequence similarity member 20C is the primary but not the only kinase for the small-integrin-binding ligand N-linked glycoproteins in bone FGF23 production by osteocytes.Fibroblast growth factor 23 and bone mineralisation.Insights from genetic disorders of phosphate homeostasis Endocrine functions of bone in mineral metabolism regulation.Relationship between plasma fibroblast growth factor-23 concentration and bone mineralization in children with renal failure on peritoneal dialysis.The osteocyte: an endocrine cell ... and more.A systems biology preview of the relationships between mineral and metabolic complications in chronic kidney disease.Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease.Is fibroblast growth factor 23 a harbinger of mortality in CKD?Osteocytes: central conductors of bone biology in normal and pathological conditions.Tooth dentin defects reflect genetic disorders affecting bone mineralization.Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?The Role of the Osteocyte in Bone and Nonbone Disease.

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P2860

Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

Item

http://www.wikidata.org/entity/Q35975746

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

2007年论文

@zh

2007年论文

@zh-cn

name

Phosphorylated acidic serine-a ...... e X-chromosome enzyme activity

@ast

Phosphorylated acidic serine-a ...... e X-chromosome enzyme activity

@en

type

Item

label

Phosphorylated acidic serine-a ...... e X-chromosome enzyme activity

@ast

Phosphorylated acidic serine-a ...... e X-chromosome enzyme activity

@en

prefLabel

Phosphorylated acidic serine-a ...... e X-chromosome enzyme activity

@ast

Phosphorylated acidic serine-a ...... e X-chromosome enzyme activity

@en

P1476

Phosphorylated acidic serine-a ...... e X-chromosome enzyme activity

@en

P2093

Jianping Zhou

http://www.w3.org/2001/XMLSchema#string

Luke Vierthaler

http://www.w3.org/2001/XMLSchema#string

Peter S N Rowe

http://www.w3.org/2001/XMLSchema#string

Shiguang Liu

http://www.w3.org/2001/XMLSchema#string

P2860

MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium

Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency

Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins

Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23

Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia

Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes

P304

261-267

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P31

scholarly article

P356

10.1677/JOE.1.07059

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

192

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P50

L. Darryl Quarles

P577

2007-01-01T00:00:00Z

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P5875

6590127

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P698

17210763

http://www.w3.org/2001/XMLSchema#string

P921

extracellular matrix

phosphorylation

P932

3357085

http://www.w3.org/2001/XMLSchema#string

Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

about

P2860

P2860

Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P5875

P698

P921

P932