Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina
about
Retinopathy in mice induced by disrupted all-trans-retinal clearanceVitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6Retina, retinol, retinal and the natural history of vitamin A as a light sensorImportance of Membrane Structural Integrity for RPE65 Retinoid Isomerization ActivityRetinol Dehydrogenases Regulate Vitamin A Metabolism for Visual FunctionMembrane-binding and enzymatic properties of RPE65Chemistry of the retinoid (visual) cycleA splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndromeVitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding proteinVisual Cycle Modulation as an Approach toward Preservation of Retinal IntegrityChemistry and biology of the initial steps in vision: the Friedenwald lecture.Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissuesInhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desaturaRetinoids for treatment of retinal diseasesPharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment.STRA6 is critical for cellular vitamin A uptake and homeostasis.Phase ii, randomized, placebo-controlled, 90-day study of emixustat hydrochloride in geographic atrophy associated with dry age-related macular degenerationFatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase.Deuterium enrichment of vitamin A at the C20 position slows the formation of detrimental vitamin A dimers in wild-type rodentsC20-D3-vitamin A slows lipofuscin accumulation and electrophysiological retinal degeneration in a mouse model of Stargardt disease.LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration.Key enzymes of the retinoid (visual) cycle in vertebrate retinaProlonged prevention of retinal degeneration with retinylamine loaded nanoparticles.Membrane receptors and transporters involved in the function and transport of vitamin A and its derivatives.Molecular pharmacodynamics of emixustat in protection against retinal degeneration.Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium.Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding proteinMolecular biology and analytical chemistry methods used to probe the retinoid cyclePrimary amines protect against retinal degeneration in mouse models of retinopathies.Real-time analyses of retinol transport by the membrane receptor of plasma retinol binding protein.Impact of retinal disease-associated RPE65 mutations on retinoid isomerization.The retina rapidly incorporates ingested C20-D₃-vitamin A in a swine model.New insights into retinoid metabolism and cycling within the retinaSTRA6-catalyzed vitamin A influx, efflux, and exchange.Structures and biogenetic analysis of lipofuscin bis-retinoids.Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate.Two carotenoid oxygenases contribute to mammalian provitamin A metabolism.Activation of retinoic acid receptors by dihydroretinoids.
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P2860
Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina
description
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2008
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im April 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/04/11)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/04/11)
@nl
наукова стаття, опублікована у квітні 2008
@uk
name
Metabolic basis of visual cycl ...... ounds in the vertebrate retina
@ast
Metabolic basis of visual cycl ...... ounds in the vertebrate retina
@en
Metabolic basis of visual cycl ...... ounds in the vertebrate retina
@nl
type
label
Metabolic basis of visual cycl ...... ounds in the vertebrate retina
@ast
Metabolic basis of visual cycl ...... ounds in the vertebrate retina
@en
Metabolic basis of visual cycl ...... ounds in the vertebrate retina
@nl
prefLabel
Metabolic basis of visual cycl ...... ounds in the vertebrate retina
@ast
Metabolic basis of visual cycl ...... ounds in the vertebrate retina
@en
Metabolic basis of visual cycl ...... ounds in the vertebrate retina
@nl
P2093
P2860
P356
P1476
Metabolic basis of visual cycl ...... ounds in the vertebrate retina
@en
P2093
Akiko Maeda
Grzegorz Bereta
Marcin Golczak
Philip D. Kiser
Silke Hunzelmann
Tadao Maeda
William S. Blaner
P2860
P304
P356
10.1074/JBC.M708982200
P407
P577
2008-04-11T00:00:00Z