about
The emerging roles of melanopsin in behavioral adaptation to lightHuman Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9- cis -Retinal Isomerase ActivityMolecular Basis for Vitamin A Uptake and Storage in VertebratesChemistry of the retinoid (visual) cycleSafety and Proof-of-Concept Study of Oral QLT091001 in Retinitis Pigmentosa Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT)Chemistry and biology of the initial steps in vision: the Friedenwald lecture.PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced DamageRetinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissuesSynthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration.All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis.Rational Tuning of Visual Cycle Modulator PharmacodynamicsPharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment.Retinal degeneration in animal models with a defective visual cycle.STRA6 is critical for cellular vitamin A uptake and homeostasis.Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.Human cone visual pigment deletions spare sufficient photoreceptors to warrant gene therapyQLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles.Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice.Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations.Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration.Key enzymes of the retinoid (visual) cycle in vertebrate retinaDietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosisMetabolism of carotenoids and retinoids related to vision.Improvement in vision: a new goal for treatment of hereditary retinal degenerationsA High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.Molecular pharmacodynamics of emixustat in protection against retinal degeneration.The G protein-coupled receptor rhodopsin: a historical perspectiveRetinal photodamage mediated by all-trans-retinal.Cardiac Optogenetics: Enhancement by All-trans-Retinal.A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids.Provitamin A metabolism and functions in mammalian biology.A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesisPhotoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease.Vitamin A derivatives as treatment options for retinal degenerative diseases.New insights into retinoid metabolism and cycling within the retinaRetinoids and Retinal Diseases.Inherent instability of the retinitis pigmentosa P23H mutant opsin.Retinoic acid signaling pathways in development and diseases.Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Retinoids for treatment of retinal diseases
@ast
Retinoids for treatment of retinal diseases
@en
type
label
Retinoids for treatment of retinal diseases
@ast
Retinoids for treatment of retinal diseases
@en
prefLabel
Retinoids for treatment of retinal diseases
@ast
Retinoids for treatment of retinal diseases
@en
P2860
P1476
Retinoids for treatment of retinal diseases
@en
P2093
Krzysztof Palczewski
P2860
P304
P356
10.1016/J.TIPS.2010.03.001
P577
2010-06-01T00:00:00Z