The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis
about
Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADDRecognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domainRegulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with themRSK2 activity is regulated by its interaction with PEA-15Molecular profiles of mRNA levels in laser capture microdissected murine hippocampal regions differentially responsive to TMT-induced cell death.The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin actionCharacterization of a MAPK scaffolding protein logic gate in gonadotropes.Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15.Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanismEstradiol attenuates down-regulation of PEA-15 and its two phosphorylated forms in ischemic brain injuryPEA-15 modulates TNFalpha intracellular signaling in astrocytes.High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patientsMinocycline as a neuroprotective agent.Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15.Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15.Targetting PED/PEA-15 for diabetes treatment.Melatonin prevents down-regulation of astrocytic phosphoprotein PEA-15 in ischemic brain injury.Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation.Apoptosis induced by Na+/H+ antiport inhibition activates the LEI/L-DNase II pathway.Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells.Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.Gingko biloba extract (EGb 761) attenuates the focal cerebral ischemic injury-induced decrease in astrocytic phosphoprotein PEA-15 levels.
P2860
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P2860
The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis
description
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im Dezember 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/12/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/12/01)
@nl
наукова стаття, опублікована в грудні 1999
@uk
مقالة علمية (نشرت في ديسمبر 1999)
@ar
name
The phosphoprotein protein PEA ...... spase-8 activity and apoptosis
@ast
The phosphoprotein protein PEA ...... spase-8 activity and apoptosis
@en
The phosphoprotein protein PEA ...... spase-8 activity and apoptosis
@nl
type
label
The phosphoprotein protein PEA ...... spase-8 activity and apoptosis
@ast
The phosphoprotein protein PEA ...... spase-8 activity and apoptosis
@en
The phosphoprotein protein PEA ...... spase-8 activity and apoptosis
@nl
prefLabel
The phosphoprotein protein PEA ...... spase-8 activity and apoptosis
@ast
The phosphoprotein protein PEA ...... spase-8 activity and apoptosis
@en
The phosphoprotein protein PEA ...... spase-8 activity and apoptosis
@nl
P2093
P921
P356
P1476
The phosphoprotein protein PEA ...... spase-8 activity and apoptosis
@en
P2093
A. Estellés
C. A. Charlton
H. M. Blau
P356
10.1006/DBIO.1999.9510
P407
P577
1999-12-01T00:00:00Z