RSK2 activity is regulated by its interaction with PEA-15
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Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADDActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesOn the Quest of Cellular Functions of PEA-15 and the Therapeutic OpportunitiesERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functionsPEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastomaRSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migrationCodependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survivalERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities.Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSKPhosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability.Subcellular localization and biological actions of activated RSK1 are determined by its interactions with subunits of cyclic AMP-dependent protein kinase.P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury.Characterization of a MAPK scaffolding protein logic gate in gonadotropes.MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft modelPLD1 participates in BDNF-induced signalling in cortical neuronsPhosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoterSusceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donorsActivation of p90 Rsk1 is sufficient for differentiation of PC12 cells.Ribosomal S6 kinase (RSK) modulators: a patent review.FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.Targetting PED/PEA-15 for diabetes treatment.Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation.Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms.The selective glucocorticoid receptor antagonist ORG 34116 decreases immobility time in the forced swim test and affects cAMP-responsive element-binding protein phosphorylation in rat brain.Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.
P2860
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P2860
RSK2 activity is regulated by its interaction with PEA-15
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
RSK2 activity is regulated by its interaction with PEA-15
@ast
RSK2 activity is regulated by its interaction with PEA-15
@en
RSK2 activity is regulated by its interaction with PEA-15
@nl
type
label
RSK2 activity is regulated by its interaction with PEA-15
@ast
RSK2 activity is regulated by its interaction with PEA-15
@en
RSK2 activity is regulated by its interaction with PEA-15
@nl
prefLabel
RSK2 activity is regulated by its interaction with PEA-15
@ast
RSK2 activity is regulated by its interaction with PEA-15
@en
RSK2 activity is regulated by its interaction with PEA-15
@nl
P2860
P356
P1476
RSK2 activity is regulated by its interaction with PEA-15
@en
P2093
Hema Vaidyanathan
P2860
P304
P356
10.1074/JBC.M303988200
P407
P50
P577
2003-08-22T00:00:00Z