Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality
about
Capturing structure and function in an embryonic heart with biophotonic tools.Tropomodulin capping of actin filaments in striated muscle development and physiologyConnecting teratogen-induced congenital heart defects to neural crest cells and their effect on cardiac functionDifferent localizations and cellular behaviors of leiomodin and tropomodulin in mature cardiomyocyte sarcomeresKnockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethalityMammalian E4 is required for cardiac development and maintenance of the nervous system.Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiologyTmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lensLmod2 piggyBac mutant mice exhibit dilated cardiomyopathy.Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis.Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeletonPointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers.The minus-end actin capping protein, UNC-94/tropomodulin, regulates development of the Caenorhabditis elegans intestineTropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryoEffects of smoking cessation on gene expression in human leukocytes of chronic smokerPhosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle.Erythrocyte tropomodulin isoforms with and without the N-terminal actin-binding domainDynamic regulation of sarcomeric actin filaments in striated muscleMammalian tropomodulins nucleate actin polymerization via their actin monomer binding and filament pointed end-capping activities.Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes.Tropomodulin 3 binds to actin monomers.Tropomodulins are negative regulators of neurite outgrowth.Tropomyosin-based regulation of the actin cytoskeleton in time and space.Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis.Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers.DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in DrosophilaLens ion homeostasis relies on the assembly and/or stability of large connexin 46 gap junction plaques on the broad sides of differentiating fiber cells.Thin-filament length correlates with fiber type in human skeletal muscle.Transgenic Expression of the Formin Protein Fhod3 Selectively in the Embryonic Heart: Role of Actin-Binding Activity of Fhod3 and Its Sarcomeric Localization during Myofibrillogenesis.Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortexCypher and Enigma homolog protein are essential for cardiac development and embryonic survivalTropomodulins and tropomyosins: working as a teamSarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegansTropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells.Thin filament length regulation in striated muscle sarcomeres: pointed-end dynamics go beyond a nebulin ruler.Designing heart performance by gene transfer.Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development.Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens.Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types.
P2860
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P2860
Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality
description
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
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im Dezember 2003 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2003/12/08)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/12/08)
@nl
наукова стаття, опублікована в грудні 2003
@uk
مقالة علمية (نشرت في 8-12-2003)
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name
Aberrant myofibril assembly in ...... opment and embryonic lethality
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Aberrant myofibril assembly in ...... opment and embryonic lethality
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Aberrant myofibril assembly in ...... opment and embryonic lethality
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type
label
Aberrant myofibril assembly in ...... opment and embryonic lethality
@ast
Aberrant myofibril assembly in ...... opment and embryonic lethality
@en
Aberrant myofibril assembly in ...... opment and embryonic lethality
@nl
prefLabel
Aberrant myofibril assembly in ...... opment and embryonic lethality
@ast
Aberrant myofibril assembly in ...... opment and embryonic lethality
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Aberrant myofibril assembly in ...... opment and embryonic lethality
@nl
P2093
P2860
P3181
P356
P1476
Aberrant myofibril assembly in ...... opment and embryonic lethality
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P2093
Carol C. Gregorio
Kimberly L. Fritz-Six
Patrick R. Cox
Robert S. Fischer
P2860
P304
P3181
P356
10.1083/JCB.200308164
P407
P577
2003-12-08T00:00:00Z