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The fragile X mental retardation protein inhibits translation via interacting with mRNA

The fragile X mental retardation protein inhibits translation via interacting with mRNA

http://www.wikidata.org/entity/Q28588486

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Altered synaptic plasticity in a mouse model of fragile X mental retardation Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons.Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.Targeting fragile X.Development and plasticity of the Drosophila larval neuromuscular junction Matrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome.The pathophysiology of fragile X (and what it teaches us about synapses)From Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment Channelopathies and dendritic dysfunction in fragile X syndrome.Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules Regulatory BC1 RNA and the fragile X mental retardation protein: convergent functionality in brain Structural Studies of the Tandem Tudor Domains of Fragile X Mental Retardation Related Proteins FXR1 and FXR2 Altered Translational Control of FMRP on Myelin Proteins in Neuropsychiatric Disorders Dicer-derived microRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein The fragile X gene and its function Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome RNA and microRNAs in fragile X mental retardation The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif.Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level Transport of fragile X mental retardation protein via granules in neurites of PC12 cells.Molecular phenotype of Fragile X syndrome: FMRP, FXRPs, and protein targets Modeling fragile X syndrome in the Fmr1 knockout mouse Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels.Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b Potassium channel modulation and auditory processing Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons.FMRP mediates mGluR5-dependent translation of amyloid precursor protein.Fragile X mental retardation protein regulates translation by binding directly to the ribosome The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95.Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA.Lithium: a promising treatment for fragile X syndrome.

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P2860

The fragile X mental retardation protein inhibits translation via interacting with mRNA

http://www.wikidata.org/entity/Q28588486

description

2001 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի հունիսին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2001

@ast

im Juni 2001 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2001/06/01)

@sk

vědecký článek publikovaný v roce 2001

@cs

wetenschappelijk artikel (gepubliceerd op 2001/06/01)

@nl

наукова стаття, опублікована в червні 2001

@uk

مقالة علمية (نشرت في يونيو 2001)

@ar

name

The fragile X mental retardation protein inhibits translation via interacting with mRNA

@ast

The fragile X mental retardation protein inhibits translation via interacting with mRNA

@en

The fragile X mental retardation protein inhibits translation via interacting with mRNA

@nl

type

label

The fragile X mental retardation protein inhibits translation via interacting with mRNA

@ast

The fragile X mental retardation protein inhibits translation via interacting with mRNA

@en

The fragile X mental retardation protein inhibits translation via interacting with mRNA

@nl

prefLabel

The fragile X mental retardation protein inhibits translation via interacting with mRNA

@ast

The fragile X mental retardation protein inhibits translation via interacting with mRNA

@en

The fragile X mental retardation protein inhibits translation via interacting with mRNA

@nl

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P1433

Nucleic Acids Research

P1476

The fragile X mental retardation protein inhibits translation via interacting with mRNA

@en

P2093

K. D. Wilkinson

http://www.w3.org/2001/XMLSchema#string

L. Ku

http://www.w3.org/2001/XMLSchema#string

S. T. Warren

http://www.w3.org/2001/XMLSchema#string

Y. Feng

http://www.w3.org/2001/XMLSchema#string

Y. Zhang

http://www.w3.org/2001/XMLSchema#string

Z. Li

http://www.w3.org/2001/XMLSchema#string

P2860

A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein

The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2

FMR1 protein: conserved RNP family domains and selective RNA binding

Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis

Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex

Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them

The STAR protein QKI-6 is a translational repressor

FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

Evidence that fragile X mental retardation protein is a negative regulator of translation

P304

2276–2283

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2297828

http://www.w3.org/2001/XMLSchema#string

P356

10.1093/NAR/29.11.2276

http://www.w3.org/2001/XMLSchema#string

P407

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

29

http://www.w3.org/2001/XMLSchema#string

P577

2001-06-01T00:00:00Z

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P5875

276943279

http://www.w3.org/2001/XMLSchema#string

P698

11376146

http://www.w3.org/2001/XMLSchema#string

P921

Synaptic functional regulator FMR1

P932

55699

http://www.w3.org/2001/XMLSchema#string