Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development
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The clinical spectrum of homozygous HOXA1 mutationsThe neural crest in cardiac congenital anomaliesDefective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defectsPrdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryoTbx1 regulates population, proliferation and cell fate determination of otic epithelial cellsGata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordiaRequired, tissue-specific roles for Fgf8 in outflow tract formation and remodelingHes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndromeFgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutantsGreat vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in miceMesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract developmentTbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectodermIn vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea.Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients.Mesodermal Tbx1 is required for patterning the proximal mandible in miceThe neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal archEvolutionary and developmental origins of the cardiac neural crest: building a divided outflow tractTbx1 controls the morphogenesis of pharyngeal pouch epithelia through mesodermal Wnt11r and Fgf8a.Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication.A focused in situ hybridization screen identifies candidate transcriptional regulators of thymic epithelial cell development and function.Cardiac cell lineages that form the heart.Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1p53 Suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome.Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesisHox genes define distinct progenitor sub-domains within the second heart field.Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling.Mesodermal Nkx2.5 is necessary and sufficient for early second heart field developmentTbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignmentReduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome.Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency.Tbx1 is required for second heart field proliferation in zebrafish22q11.2 deletion syndromeMore Clinical Overlap between 22q11.2 Deletion Syndrome and CHARGE Syndrome than Often Anticipated.Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract.Genetic modifiers of the physical malformations in velo-cardio-facial syndrome/DiGeorge syndrome.Understanding the role of Tbx1 as a candidate gene for 22q11.2 deletion syndrome
P2860
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P2860
Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development
description
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Dezember 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/12/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/12/01)
@nl
наукова стаття, опублікована в грудні 2005
@uk
مقالة علمية (نشرت في ديسمبر 2005)
@ar
name
Tbx1 expression in pharyngeal ...... yngeal arch artery development
@ast
Tbx1 expression in pharyngeal ...... yngeal arch artery development
@en
Tbx1 expression in pharyngeal ...... yngeal arch artery development
@nl
type
label
Tbx1 expression in pharyngeal ...... yngeal arch artery development
@ast
Tbx1 expression in pharyngeal ...... yngeal arch artery development
@en
Tbx1 expression in pharyngeal ...... yngeal arch artery development
@nl
prefLabel
Tbx1 expression in pharyngeal ...... yngeal arch artery development
@ast
Tbx1 expression in pharyngeal ...... yngeal arch artery development
@en
Tbx1 expression in pharyngeal ...... yngeal arch artery development
@nl
P2093
P3181
P356
P1433
P1476
Tbx1 expression in pharyngeal ...... yngeal arch artery development
@en
P2093
Antonio Baldini
Elizabeth Lindsay
Fabiana Cerrato
Francesca Vitelli
Huansheng Xu
James F Martin
Joshua Vincentz
Lijiang Ma
Masae Morishima
Yasuhide Furuta
P304
P3181
P356
10.1242/DEV.02086
P407
P50
P577
2005-12-01T00:00:00Z