Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
about
ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus [corrected]Gene knockout of Acc2 has little effect on body weight, fat mass, or food intakeThe human ACC2 CT-domain C-terminus is required for full functionality and has a novel twistEnergy metabolism in the liverID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liverGenetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.Treatment of nonalcoholic fatty liver disease: role of AMPK.Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.Distinct Roles for Intracellular and Extracellular Lipids in Hepatitis C Virus Infection.In vivo D2O labeling to quantify static and dynamic changes in cholesterol and cholesterol esters by high resolution LC/MS.Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanismsGenetic control of de novo lipogenesis: role in diet-induced obesityHepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.Acyl-CoA binding protein gene ablation induces pre-implantation embryonic lethality in mice.Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake.Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene.IL-1 signaling in obesity-induced hepatic lipogenesis and steatosisPhospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice.Targeted chemical-genetic regulation of protein stability in vivoMice subjected to aP2-Cre mediated ablation of microsomal triglyceride transfer protein are resistant to high fat diet induced obesityContribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice.Aryl Hydrocarbon Receptor Plays Protective Roles against High Fat Diet (HFD)-induced Hepatic Steatosis and the Subsequent Lipotoxicity via Direct Transcriptional Regulation of Socs3 Gene ExpressionAcetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver DiseaseInhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cellsLack of mitochondria-generated acetyl-CoA by pyruvate dehydrogenase complex downregulates gene expression in the hepatic de novo lipogenic pathway.Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.Hepatic fatty acid trafficking: multiple forks in the roadInhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008.Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver.New insights from rodent models of fatty liver diseaseThe mechanistic basis for the induction of hepatic steatosis by xenobiotics.The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis.Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer.Constitutive expression of microRNA-150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis.HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD.Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition.ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis.
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P2860
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
description
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im März 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/03/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/03/01)
@nl
наукова стаття, опублікована в березні 2007
@uk
مقالة علمية (نشرت في مارس 2007)
@ar
name
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
@ast
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
@en
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
@nl
type
label
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
@ast
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
@en
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
@nl
prefLabel
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
@ast
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
@en
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
@nl
P2093
P2860
P3181
P356
P1476
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
@en
P2093
Jun Kusunoki
Katsumi Aragane
Kenji Ohwaki
Koji Fujinami
Mari Yonemoto
Mayumi Okawa
Naomoto Harada
Yoshikazu Hara
Yoshitaka Tamai
Yuika Ikeda
P2860
P304
P3181
P356
10.1128/MCB.01122-06
P407
P577
2007-01-08T00:00:00Z