Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
about
Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulumTapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathwayUbiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?Tapasin enhances MHC class I peptide presentation according to peptide half-lifeDifferential expression of tapasin and immunoproteasome subunits in adenovirus type 5- versus type 12-transformed cellsIdentification of an alternate splice form of tapasin in human melanoma.The binding of TAPBPR and Tapasin to MHC class I is mutually exclusive.Mapping and expression pattern analysis of key components of the major histocompatibility complex class I antigen processing and presentation pathway in a representative human renal cell carcinoma cell line.Human cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responsesPathways of antigen processing.Requirements for the selective degradation of endoplasmic reticulum-resident major histocompatibility complex class I proteins by the viral immune evasion molecule mK3.Modes of calreticulin recruitment to the major histocompatibility complex class I assembly pathwayTAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway.Mechanisms of function of tapasin, a critical major histocompatibility complex class I assembly factorTapasin modification on the intracellular epitope HBcAg18-27 enhances HBV-specific CTL immune response and inhibits hepatitis B virus replication in vivo.A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I moleculesEndoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.Major histocompatibility complex class I-restricted antigen processing and presentation.Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.Direct peptide-regulatable interactions between MHC class I molecules and tapasin.Tapasin and other chaperones: models of the MHC class I loading complex.Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer.In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib moleculesAccessory molecules in the assembly of major histocompatibility complex class I/peptide complexes: how essential are they for CD8(+) T-cell immune responses?The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex.Recognition of open conformers of classical MHC by chaperones and monoclonal antibodies.Antigen presentation machinery (APM) modulation and soluble HLA molecules in the tumor microenvironment: do they provide tumor cells with escape mechanisms from recognition by cytotoxic T lymphocytes?Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigensThe role of tapasin in MHC class I protein trafficking in embryos and T cells.The double role of the endoplasmic reticulum chaperone tapasin in peptide optimization of HLA class I molecules.ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.Viral proteins interfering with antigen presentation target the major histocompatibility complex class I peptide-loading complex.Redox-regulated export of the major histocompatibility complex class I-peptide complexes from the endoplasmic reticulumAdapter-mediated substrate selection for endoplasmic reticulum-associated degradation.The quality control of MHC class I peptide loading.Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition.Molecular mechanisms of IFN-gamma to up-regulate MHC class I antigen processing and presentation.Severe combined immunodeficiences: new and old scenarios.The multi-faceted nature of HLA class I dimer molecules.
P2860
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P2860
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
description
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im August 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/08/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/08/01)
@nl
наукова стаття, опублікована в серпні 2000
@uk
مقالة علمية (نشرت في أغسطس 2000)
@ar
name
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
@ast
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
@en
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
@nl
type
label
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
@ast
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
@en
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
@nl
prefLabel
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
@ast
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
@en
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
@nl
P2093
P1433
P1476
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice
@en
P2093
A. G. Grandea
J. T. Harty
L. C. Eisenlohr
L. Van Kaer
R. R. Brutkiewicz
S. E. Hamilton
T. N. Golovina
P304
P356
10.1016/S1074-7613(00)00021-2
P407
P577
2000-08-01T00:00:00Z