In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules
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Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-PresentationStructural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen ProcessingIRAP identifies an endosomal compartment required for MHC class I cross-presentationERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulumNonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulumThe synovio-entheseal complex in enthesoarthritis.The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.Distinct signature of altered homeostasis in aging rod photoreceptors: implications for retinal diseases.HLA-B*51 the primary risk in Behçet disease.The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentationPlacental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.Targeted delivery of an antigenic peptide to the endoplasmic reticulum: application for development of a peptide therapy for ankylosing spondylitis.Differences in genetic variation in antigen-processing machinery components and association with cervical carcinoma risk in two Indonesian populations.Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation.The role of insulin-regulated aminopeptidase in MHC class I antigen presentation.ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responsesThe saga of MHC-bound peptides: a renaissance for antigen presentation?Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma.Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis.Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigensComparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypesNon-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance.Coping with loss of perfection in the MHC class I peptide repertoire.ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum.ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.The quality control of MHC class I peptide loading.Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum.Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.
P2860
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P2860
In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
In vivo role of ER-associated ...... lass Ia and class Ib molecules
@ast
In vivo role of ER-associated ...... lass Ia and class Ib molecules
@en
type
label
In vivo role of ER-associated ...... lass Ia and class Ib molecules
@ast
In vivo role of ER-associated ...... lass Ia and class Ib molecules
@en
prefLabel
In vivo role of ER-associated ...... lass Ia and class Ib molecules
@ast
In vivo role of ER-associated ...... lass Ia and class Ib molecules
@en
P2093
P2860
P50
P356
P1476
In vivo role of ER-associated ...... lass Ia and class Ib molecules
@en
P2093
Derry C Roopenian
Jingbo Yan
Srdjan Dragovic
Timothy Hill
Vrajesh V Parekh
Yanice Mendez-Fernandez
P2860
P304
P356
10.1084/JEM.20052271
P407
P577
2006-02-27T00:00:00Z