Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion
about
Human and rat beta cells differ in glucose transporter but not in glucokinase gene expressionPancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucoseAnimal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase geneMice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulationNuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint.Current status of ribozymes as gene therapy agents for cancer.Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration.Of mice and models: improved animal models for biomedical research.RNases involved in ribozyme degradation in Escherichia coliDiet-dependent hypercalciuria in transgenic mice with reduced CLC5 chloride channel expression.Inhibition of HPV-16 E6/E7 immortalization of normal keratinocytes by hairpin ribozymes.Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase.Essential role of mitochondrially encoded large rRNA for germ-line formation in Drosophila embryosDose-response resistance to HIV-1/MuLV pseudotype virus ex vivo in a hairpin ribozyme transgenic mouse model.G6PC2: a negative regulator of basal glucose-stimulated insulin secretionThe glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.Efficient and specific ribozyme-mediated reduction of bovine alpha-lactalbumin expression in double transgenic mice.Glucose transporters: physiological and pathological roles.Reduced beta 2-microglobulin mRNA levels in transgenic mice expressing a designed hammerhead ribozyme.Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes.A three-nucleotide helix I is sufficient for full activity of a hammerhead ribozyme: advantages of an asymmetric design.Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes.Ribozymes: structure, function, and potential therapy for dominant genetic disorders.Effects of glucose refeeding and glibenclamide treatment on glucokinase and GLUT2 gene expression in pancreatic B-cells and liver from rats.Efficient hammerhead ribozymes targeted to the polycistronic Sendai virus P/C mRNA. Structure-function relationships.
P2860
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P2860
Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion
description
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1994
@ast
im März 1994 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1994/03/15)
@sk
vědecký článek publikovaný v roce 1994
@cs
wetenschappelijk artikel (gepubliceerd op 1994/03/15)
@nl
наукова стаття, опублікована в березні 1994
@uk
name
Ribozyme-mediated attenuation ...... cose-induced insulin secretion
@ast
Ribozyme-mediated attenuation ...... cose-induced insulin secretion
@en
Ribozyme-mediated attenuation ...... cose-induced insulin secretion
@nl
type
label
Ribozyme-mediated attenuation ...... cose-induced insulin secretion
@ast
Ribozyme-mediated attenuation ...... cose-induced insulin secretion
@en
Ribozyme-mediated attenuation ...... cose-induced insulin secretion
@nl
prefLabel
Ribozyme-mediated attenuation ...... cose-induced insulin secretion
@ast
Ribozyme-mediated attenuation ...... cose-induced insulin secretion
@en
Ribozyme-mediated attenuation ...... cose-induced insulin secretion
@nl
P2093
P2860
P921
P356
P1476
Ribozyme-mediated attenuation ...... cose-induced insulin secretion
@en
P2093
D. Fusco-DeMane
M. A. Magnuson
N. Fleischer
O. A. Emran
T. L. Jetton
P2860
P304
P356
10.1073/PNAS.91.6.2051
P407
P50
P577
1994-03-15T00:00:00Z