Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes.
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Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymesRedesigned and chemically-modified hammerhead ribozymes with improved activity and serum stabilityAutomated design of hammerhead ribozymes and validation by targeting the PABPN1 gene transcript.Recent advances in the elucidation of the mechanisms of action of ribozymesConstruction of a directed hammerhead ribozyme library: towards the identification of optimal target sites for antisense-mediated gene inhibition.Current status of ribozymes as gene therapy agents for cancer.Synthetic hammerhead ribozymes as tools in gene expression.Characterization of several kinds of dimer minizyme: simultaneous cleavage at two sites in HIV-1 tat mRNA by dimer minizymes.Selection of the best target site for ribozyme-mediated cleavage within a fusion gene for adenovirus E1A-associated 300 kDa protein (p300) and luciferase.Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNACleavage of collagen RNA transcripts by hammerhead ribozymes in vitro is mutation-specific and shows competitive binding effectsVariables and strategies in development of therapeutic post-transcriptional gene silencing agentsOrganelle trafficking of chimeric ribozymes and genetic manipulation of mitochondria.Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy.Use of intrinsic binding energy for catalysis by an RNA enzymeIdentifying ribozyme-accessible sites using NUH triplet-targeting gapmers.Effects of the trinucleotide preceding the self-cleavage site on eggplant latent viroid hammerheads: differences in co- and post-transcriptional self-cleavage may explain the lack of trinucleotide AUC in most natural hammerheadsUnexpected anisotropy in substrate cleavage rates by asymmetric hammerhead ribozymes.In vitro selection of hammerhead ribozymes containing a bulged nucleotide in stem II.The subcellular localization and length of hammerhead ribozymes determine efficacy in human cells.A spermidine-induced conformational change of long-armed hammerhead ribozymes: ionic requirements for fast cleavage kinetics.Extending the cleavage rules for the hammerhead ribozyme: mutating adenosine15.1 to inosine15.1 changes the cleavage site specificity from N16.2U16.1H17 to N16.2C16.1H17.Sequence specificity of the hammerhead ribozyme revisited; the NHH rule.Identification of a caspase 3-independent role of pro-apoptotic factor Bak in TNF-alpha-induced apoptosis.Functional disruption of IEX-1 expression by concatemeric hammerhead ribozymes alters growth properties of 293 cells.Ribozymes: structure, function, and potential therapy for dominant genetic disorders.A cellular high-throughput screening approach for therapeutic trans-cleaving ribozymes and RNAi against arbitrary mRNA disease targets.G17-modified hammerhead ribozymes are active in vitro and in vivo.A strategy for developing a hammerhead ribozyme for selective RNA cleavage depending on substitutional RNA editing.Re-characterization of hammerhead ribozymes as molecular tools for intermolecular RNA cleavage.
P2860
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P2860
Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Comparative analysis of cleava ...... otif for hammerhead ribozymes.
@en
type
label
Comparative analysis of cleava ...... otif for hammerhead ribozymes.
@en
prefLabel
Comparative analysis of cleava ...... otif for hammerhead ribozymes.
@en
P2860
P356
P1476
Comparative analysis of cleava ...... otif for hammerhead ribozymes.
@en
P2093
Zoumadakis M
P2860
P304
P356
10.1093/NAR/23.7.1192
P577
1995-04-01T00:00:00Z