Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos
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Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivativesIdentification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolismTeratogenic mechanisms of medical drugsCraniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acidIdentification of all-trans-retinol:all-trans-13,14-dihydroretinol saturaseRetinoid-binding proteins: mediators of retinoid actionTranscriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibilityRemoval of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cellsThe discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression systemPharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis.Long-distance retinoid signaling in the zebra finch brainCytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducibleAssociation of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductaseThe retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryoThe retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures.4-hydroxyretinoic acid, a novel substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7Dynamic expression of retinoic acid-synthesizing and -metabolizing enzymes in the developing mouse inner ear.Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alphaContribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse developmentRequirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformationSpatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous systemMetabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retinaTargeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retinaShifting boundaries of retinoic acid activity control hindbrain segmental gene expressionApplication of synthetic photostable retinoids induces novel limb and facial phenotypes during chick embryogenesis in vivoRetinoic acid is a potential dorsalising signal in the late embryonic chick hindbrain.Differential expression of chicken CYP26 in anterior versus posterior limb bud in response to retinoic acid.Neuronal regulation of the spatial patterning of neurogenesisSignaling gradients during paraxial mesoderm development.Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylaseHeads or tails? Retinoic acid will decide.Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.Retinoic Acid signalling and the control of meiotic entry in the human fetal gonadRetinoids in chemoprevention and differentiation therapy.Multiple retinoic acid response elements cooperate to enhance the inducibility of CYP26A1 gene expression in liverCloning and functional studies of a splice variant of CYP26B1 expressed in vascular cellsMetabolism and transactivation activity of 13,14-dihydroretinoic acid.Therapeutic potential of the inhibition of the retinoic acid hydroxylases CYP26A1 and CYP26B1 by xenobiotics.Hindbrain patterning revisited: timing and effects of retinoic acid signalling.Spatiotemporal retinoid-X receptor activation detected in live vertebrate embryos
P2860
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P2860
Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Metabolic inactivation of reti ...... ed in developing mouse embryos
@ast
Metabolic inactivation of reti ...... ed in developing mouse embryos
@en
Metabolic inactivation of reti ...... ed in developing mouse embryos
@nl
type
label
Metabolic inactivation of reti ...... ed in developing mouse embryos
@ast
Metabolic inactivation of reti ...... ed in developing mouse embryos
@en
Metabolic inactivation of reti ...... ed in developing mouse embryos
@nl
prefLabel
Metabolic inactivation of reti ...... ed in developing mouse embryos
@ast
Metabolic inactivation of reti ...... ed in developing mouse embryos
@en
Metabolic inactivation of reti ...... ed in developing mouse embryos
@nl
P2093
P2860
P356
P1433
P1476
Metabolic inactivation of reti ...... ed in developing mouse embryos
@en
P2093
Y Fujii-Kuriyama
P2860
P304
P356
10.1093/EMBOJ/16.14.4163
P407
P577
1997-07-01T00:00:00Z