The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability
about
Krüppel-like factors: three fingers in controlSystematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approachHaploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobinA dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemiaDistinct modes of gene regulation by a cell-specific transcriptional activatorErythroid phenotypes associated with KLF1 mutationsThe CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivoKruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesisMammalian Krüppel-like factors in health and diseasesA network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivoEKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesisA global role for EKLF in definitive and primitive erythropoiesisKrüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variantsGarlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesisA Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid developmentGaucher disease: transcriptome analyses using microarray or mRNA sequencing in a Gba1 mutant mouse model treated with velaglucerase alfa or imigluceraseEndoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2.Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture.Identification of erythroid-enriched gene expression in the mouse embryonic yolk sac using microdissected cells.Single cell transcriptomics reveals unanticipated features of early hematopoietic precursorsActivation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells.Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiationKrüppel-like factor 2 regulated gene expression in mouse embryonic yolk sac erythroid cells.Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.Clinical aspects and pathogenesis of congenital dyserythropoietic anemias: from morphology to molecular approach.Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor EklfGeneration of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencingRegulation of delta-aminolevulinic acid dehydratase by krüppel-like factor 1.Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XLErythropoiesis: development and differentiation.Transcriptional control of erythropoiesis: emerging mechanisms and principles.Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.Cutting edge: The transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORγtCompound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin.Lineage-specific activators affect beta-globin locus chromatin in multipotent hematopoietic progenitors.A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryoTranscription factor networks in erythroid cell and megakaryocyte developmentGenome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation.Malat1 as an evolutionarily conserved lncRNA, plays a positive role in regulating proliferation and maintaining undifferentiated status of early-stage hematopoietic cells.
P2860
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P2860
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability
description
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Juni 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/06/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/06/01)
@nl
наукова стаття, опублікована в червні 2005
@uk
مقالة علمية (نشرت في يونيو 2005)
@ar
name
The erythroid phenotype of EKL ...... abolism and membrane stability
@ast
The erythroid phenotype of EKL ...... abolism and membrane stability
@en
The erythroid phenotype of EKL ...... abolism and membrane stability
@nl
type
label
The erythroid phenotype of EKL ...... abolism and membrane stability
@ast
The erythroid phenotype of EKL ...... abolism and membrane stability
@en
The erythroid phenotype of EKL ...... abolism and membrane stability
@nl
prefLabel
The erythroid phenotype of EKL ...... abolism and membrane stability
@ast
The erythroid phenotype of EKL ...... abolism and membrane stability
@en
The erythroid phenotype of EKL ...... abolism and membrane stability
@nl
P2093
P2860
P3181
P1476
The erythroid phenotype of EKL ...... abolism and membrane stability
@en
P2093
Andrea Kolbus
Frank Grosveld
Hartmut Beug
Marieke von Lindern
Peter Steinlein
Roy Drissen
Sjaak Philipsen
P2860
P304
P3181
P356
10.1128/MCB.25.12.5205-5214.2005
P407
P577
2005-06-01T00:00:00Z